13171-25-0 Trimetazidine 2HCl AKSci J10512
 
 
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  J10512    AKSci Reference Standard
Trimetazidine 2HCl
, 98% (HPLC), powder
 
Kyurinett
Trimetajust
Lubomail
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IDENTITY
CAS Number:13171-25-0
MDL Number:MFCD00243086
MF:C14H24Cl2N2O3
MW:339.26
EINECS:236-117-0
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC), powder
Spectra:LCMS, HPLC
Physical Form:White to light yellow powder
Melting Point:200-210°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Application(s):Vasodilator Agent; Fatty Acid Oxidation Inhibitor
Form:HCl salt

REVIEW

 Trimetazidine is an anti-ischemic (anti-anginal) metabolic agent, which improves myocardial glucose utilization through inhibition of fatty acid metabolism, also known as fatty acid oxidation inhibitor. By preserving the energy metabolism in cells exposed to hypoxia or ischemia, trimetazidine prevents a decrease in intracellular adenosine triphosphate levels, thereby ensuring the proper functioning of ionic pumps and transmembranous sodium-potassium flow whilst maintaining cellular homeostasis. It also inhibits oxidation of fatty acid in blood vessels.

REFERENCES
[1]Masmoudi K, Masson H, Gras V, Andréjak M (2012). Extrapyramidal adverse drug reactions associated with trimetazidine: a series of 21 cases. Fundam Clin Pharmacol. 26(2):198-203. PMID 22044594.
[2] Zhang L, Lu Y, Jiang H, Zhang L, Sun A, Zou Y, Ge J (2012). Additional use of trimetazidine in patients with chronic heart failure: a meta-analysis. J Am Coll Cardiol. 59(10):913-22. PMID 22381427.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 16, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


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