68786-66-3 Triclabendazole AKSci J10510
 
 
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  J10510    AKSci Reference Standard
Triclabendazole, 99% (HPLC), powder
 
5-Chloro-6-(2,3-dichlorophenoxy)-2-(methylthio)-1H-benzimidazole
IDENTITY
CAS Number:68786-66-3
MDL Number:MFCD00864519
MF:C14H9Cl3N2OS
MW:359.66
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:174-176°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Triclabendazole is a benzimidazole-based anthelmintic used in human and animals. It is considered the drug of first choice against liver flukes. Its mode of action is to bind to beta-tubulin and prevent the polymerization of microtubules, impairing intracellular transport mechanisms and interfering with protein synthesis. Triclabendazole is specifically active against Fasciola, Fascioloides and Paragonimus.

REFERENCES
[1]Gallay, Jean Jacques; Kuehne, Manfred; Meyer, Alfred; Rechsteiner, Oswald; Schellenbaum, Max Anthelmintic composition Ger. Offen. (1978), DE 2815621 A1 19781019.
[2] Iddon, Brian; Kutschy, Peter; Robinson, Andrew G.; Suschitzky, Hans; Kramer, Walter; Neugebauer, Franz A 2H-Benzimidazoles (isobenzimidazoles). Part 7. A new route to triclabendazole [5-chloro-6-(2,3-dichlorophenoxy)-2-methylthio-1H-benzimidazole] and congeneric benzimidazoles Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1992), (22), 3129-34.
[3] The treatment of human fascioliasis with triclabendazole. Caminal Montero L, Fernández Fernández C, de Quirós JF, Parra F. Rev Clin Esp. 1999 May;199(5):333-5.
[4] Köhler P.The biochemical basis of anthelmintic action and resistance. Int J Parasitol. 2001 Apr;31(4):336-45.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
None

Hazard Statements
H413

Precautionary Statements
P273; P501

Current as of October 9, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antiparasitics


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