53902-12-8 Tranilast AKSci J10509
 
 
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  J10509    AKSci Reference Standard
Tranilast
, >98% (HPLC), powder
 
2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propenyl]amino] benzoic acid
N-(3,4-Dimethoxycinnamoyl)anthranilic acid
Rizaben
more..




IDENTITY
CAS Number:53902-12-8
MDL Number:MFCD00864787
MF:C18H17NO5
MW:327.33
BRN:3987703
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC), powder
Spectra:LCMS, HPLC
Physical Form:White to yellow crystalline powder
Melting Point:206-214°C
Long-Term Storage:Store long-term at 2-8°C

BIOLOGICAL INFO
Solubility:DMSO 66mg/mL; H2O: insoluble
Application(s):Calcium Channel Blocker; Histamine H1 Antagonist; Platelet Aggregation Inhibitor
Form:Free Base

REVIEW

 Tranilast is an antiallergic drug for bronchial asthma. Tranilast exerts its anti-inflammatory and anti-angiogenesis effects through inhibition of expression of MCP-1, TGF-β, and antigen-induced IL-2 lymphocyte responsiveness.

REFERENCES
[1]Sato, Tadashi Preparation of N-(3,4-dimethoxycinnamoyl)anthranilic acid as allergy inhibitor Jpn. Kokai Tokkyo Koho (1991), JP 03024046 A 19910201.
[2] Mizukoshi, Seishi Preparation of tranilast Jpn. Kokai Tokkyo Koho (1992), JP 04149165 A 19920522.
[3] Konneh, Matthew Tranilast Kissei Pharmaceutical IDrugs (1998), 1(1), 141-146.
[4] Spitzer MS, Sat M, Schramm C, Schnichels S, Schultheiss M, Yoeruek E, Dzhelebov D, Szurman P (2012). Biocompatibility and antifibrotic effect of UV-cross-linked hyaluronate as a release-system for tranilast after trabeculectomy in a rabbit model--a pilot study. Curr Eye Res. 37(6):463-70. PMID 22577763.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of October 20, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Asthma


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