REVIEW An anti-herpesvirus antiviral drug, used primarily on the eye. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing.
REFERENCES
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Srivastav NC, Mak M, Agrawal B, Tyrrell DL, Kumar R (2010). Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus. Bioorg Med Chem Lett. 20(22):6790-3. PMID 20863701.
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Suzuki N, Emura T, Fukushima M (2011). Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 39(1):263-70. PMID 21491084.
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