70-00-8 Trifluridine AKSci J10508
 
 
Loading Please Wait...
  J10508    AKSci Reference Standard
Trifluridine
, 99% (HPLC), powder
 
Trifluorothymidine
2'-Deoxy-5-trifluoromethyluridine
Trifluorothymine deoxyriboside
more..




IDENTITY
CAS Number:70-00-8
MDL Number:MFCD00006534
MF:C10H11F3N2O5
MW:296.20
EINECS:200-722-8
BRN:568095
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Spectra:LCMS, FT-IR, HPLC, Polarimetry
Physical Form:White powder
Melting Point:186-193°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 59mg/mL; H2O: 59mg/mL; EtOH: 59mg/mL
Application(s):Thymidylate synthase
Form:Free Base

REVIEW

 An anti-herpesvirus antiviral drug, used primarily on the eye. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing.

REFERENCES
[1]Srivastav NC, Mak M, Agrawal B, Tyrrell DL, Kumar R (2010). Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus. Bioorg Med Chem Lett. 20(22):6790-3. PMID 20863701.
[2] Suzuki N, Emura T, Fukushima M (2011). Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 39(1):263-70. PMID 21491084.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332; H351

Precautionary Statements
P201; P202; P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P308+P313; P322; P330; P363; P405; P501


Current as of September 21, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.


CATEGORIES

 APIs and Bioactives > Antivirals
 Nucleobases > Nucleosides
 Nucleobases > Nucleosides


PubChem