70-00-8 Trifluridine AKSci J10508
 
 
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  J10508    AKSci Reference Standard
Trifluridine, 99% (HPLC), powder
 
Trifluorothymidine
2'-Deoxy-5-trifluoromethyluridine
Trifluorothymine deoxyriboside
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IDENTITY
CAS Number:70-00-8
MDL Number:MFCD00006534
MF:C10H11F3N2O5
MW:296.20
EINECS:200-722-8
BRN:568095
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:186-193°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 59mg/mL; H2O: 59mg/mL; EtOH: 59mg/mL
Application(s):Thymidylate synthase
Form:Free Base

REVIEW
 An anti-herpesvirus antiviral drug, used primarily on the eye. It is a nucleoside analogue, a modified form of deoxyuridine, similar enough to be incorporated into viral DNA replication, but the -CF3 group added to the uracil component blocks base pairing.

REFERENCES
[1]Srivastav NC, Mak M, Agrawal B, Tyrrell DL, Kumar R (2010). Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus. Bioorg Med Chem Lett. 20(22):6790-3. PMID 20863701.
[2] Suzuki N, Emura T, Fukushima M (2011). Mode of action of trifluorothymidine (TFT) against DNA replication and repair enzymes. Int J Oncol. 39(1):263-70. PMID 21491084.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332; H351

Precautionary Statements
P201; P202; P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P308+P313; P322; P330; P363; P405; P501

Current as of June 26, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antivirals
 Nucleobases > Nucleosides
 Nucleobases > Nucleosides


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