146-77-0 2-Chloroadenosine AKSci J10503
 
 
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  J10503    AKSci Reference Standard
2-Chloroadenosine
, >98% (HPLC), powder
 



IDENTITY
CAS Number:146-77-0
MDL Number:MFCD00005734
MF:C10H12ClN5O4
MW:301.69
EINECS:205-678-3
BRN:43957
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Spectra:FT-IR, LCMS, HPLC
Physical Form:White to light yellow powder
Long-Term Storage:Store at room temperature
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):An Adenosine A receptor agonist

REVIEW

 2-Chloroadenosine is a metabolically stable analog of adenosine that behaves as an Adenosine A Receptor agonist (Ki values are 300, 80 and 1900 nM for Adenosine A1-R, Adenosine A2A-R and Adenosine A3-R, respectively). IC50 data: Adenosine A1 receptor: IC50 = 37 nM (rat); Adenosine A2 receptor: IC50 = 160 nM (rat); rat: IC50 = 620 nM; HEp-2: IC50 = 3 µM (human); Plasmodium falciparum: IC50 = 7.94 µM. Ki data: Adenosine receptor: Ki= 1.3 nM (rat); Adenosine A1 receptor: Ki= 6.7 nM (rat); A2A receptor: Ki= 80 nM; A1 receptor: Ki= 300 nM; A3 receptor: Ki= 1.9 µM.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of September 27, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 Nucleobases > Nucleosides


PubChem