73536-69-3 Bifendate AKSci J10491
 
 
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  J10491    
Bifendate, >98% (HPLC)
 
7,7'-Dimethoxy-(4,4'-bi-1,3-benzodioxole)-5,5'-dicarboxylic acid dimethyl ester
Bifendatatum
CCRIS 7767
IDENTITY
CAS Number:73536-69-3
MDL Number:MFCD01751431
MF:C20H18O10
MW:418.35
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:180-183°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Adjuvant; Enzyme Inhibitor
Form:Free base

REVIEW
 Bifendate is a synthetic intermediate of schisandrin C, a dibenzocyclooctadiene derivative derived from lignans used in traditional medicine. Bifendate has been used in some countries as a hepatoprotectant adjuvant in the treatment of liver diseases, such as chronic viral hepatitis or drug-induced hepatic damage.

REFERENCES
[1]Xie, Jingxi; Zhou, Jin; Zhang, Chunzhen; Yang, Jinghua; Jin, Hanqing; Chen, Xiaxi Synthesis of dimethyl 4,4'-dimethoxy-5,6,5',6'-bis(methylenedioxy)biphenyl-2,2'-dicarboxylate and its isomers Yaoxue Tongbao (1981), 16(7), 56-7.
[2] Kimura, Masayuki; Hosaka, Kunio; Takeda, Shigehumi; Mitsuhashi, Hiroshi Biphenyl derivatives, their preparation, and antihepatopathic agents containing them PCT Int. Appl. (1987), WO 8707272 A1 19871203.
[3] Hung HY, Nakagawa-Goto K, Tokuda H, Iida A, Suzuki N, Morris-Natschke SL, Lee KH )2012). Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents(?). Pharm Biol. 50(1):18-24. PMID 22196579.
[4] Xie Y, Wang G, Wang H, Yao X, Jiang S, Kang A, Zhou F, Xie T, Hao H (2012). Cytochrome P450 dysregulations in thioacetamide-induced liver cirrhosis in rats and the counteracting effects of hepatoprotective agents. Drug Metab Dispos. 40(4):796-802. PMID 22266841.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 13, 2025


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