REVIEW A synthetic chemotherapeutic antibacterial agent occasionally used to treat common as well as complicated urinary tract infections. Norfloxacin is a broad-spectrum antibiotic that is active against both Gram-positive and Gram-negative bacteria. It functions by inhibiting DNA gyrase, a type II topoisomerase, and topoisomerase IV, enzymes necessary to separate bacterial DNA, thereby inhibiting cell division.
REFERENCES
[1]
Dwyer DJ, Camacho DM, Kohanski MA, Callura JM, Collins JJ (2012). Antibiotic-induced bacterial cell death exhibits physiological and biochemical hallmarks of apoptosis. Mol Cell. 46(5):561-72. PMID 22633370.
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Yang JF, Ying GG, Liu S, Zhou LJ, Zhao JL, Tao R, Peng PA (2012). Biological degradation and microbial function effect of norfloxacin in a soil under different conditions. J Environ Sci Health B. 47(4):288-95. PMID 22428890.
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