75530-68-6 Nilvadipine AKSci J10461
 
 
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  J10461    AKSci Reference Standard
Nilvadipine, 99% (HPLC)
 
2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester
5-Isopropyl 3-Methyl 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate
IDENTITY
CAS Number:75530-68-6
MDL Number:MFCD00867065
MF:C19H19N3O6
MW:385.37
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:148-153°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Calcium channel blocker

REVIEW
 Nilvadipine is a racemic dihydropyridine calcium channel blocker for the treatment of hypertension and chronic major cerebral artery occlusion. It inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

REFERENCES
[1]Sato, Yoshinari 2-Methyldihydropyridine derivatives and pharmaceutical composition containing it Ger. Offen. (1980), DE 2940833 A1 19800430.
[2] Satu, Yoshinari 1,4-Dihydropyridine derivatives, and their pharmaceutical use U.S. (1981), US 4284634 A 19810818.
[3] Satoh, Yoshinari; Ichihashi, Masaharu; Okumura, Kazuo Studies on nilvadipine. I. Synthesis and structure-activity relationships of 1,4-dihydropyridines containing novel substituents at the 2-position Chemical & Pharmaceutical Bulletin (1991), 39(12), 3189-201.
[4] Honerjäger P, Seibel K, Pharmacodynamics of nilvadipine, a new dihydropyridine-type calcium antagonist. J Cardiovasc Pharmacol. 1992;20 Suppl 6:S15-21.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of April 20, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


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