75530-68-6 Nilvadipine AKSci J10461
 
 
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  J10461    
Nilvadipine
, 99% (HPLC)
 
2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 5-Isopropyl 3-Methyl Ester
5-Isopropyl 3-Methyl 2-Cyano-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate




IDENTITY
CAS Number:75530-68-6
MDL Number:MFCD00867065
MF:C19H19N3O6
MW:385.37
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:Yellow powder
Melting Point:148-153°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Application(s):Calcium channel blocker

REVIEW

 Nilvadipine is a racemic dihydropyridine calcium channel blocker for the treatment of hypertension and chronic major cerebral artery occlusion. It inhibits the influx of extracellular calcium through myocardial and vascular membrane pores by physically plugging the channel. The decrease in intracellular calcium inhibits the contractile processes of smooth muscle cells, causing dilation of the coronary and systemic arteries, increased oxygen delivery to the myocardial tissue, decreased total peripheral resistance, decreased systemic blood pressure, and decreased afterload.

REFERENCES
[1]Sato, Yoshinari 2-Methyldihydropyridine derivatives and pharmaceutical composition containing it Ger. Offen. (1980), DE 2940833 A1 19800430.
[2] Satu, Yoshinari 1,4-Dihydropyridine derivatives, and their pharmaceutical use U.S. (1981), US 4284634 A 19810818.
[3] Satoh, Yoshinari; Ichihashi, Masaharu; Okumura, Kazuo Studies on nilvadipine. I. Synthesis and structure-activity relationships of 1,4-dihydropyridines containing novel substituents at the 2-position Chemical & Pharmaceutical Bulletin (1991), 39(12), 3189-201.
[4] Honerjäger P, Seibel K, Pharmacodynamics of nilvadipine, a new dihydropyridine-type calcium antagonist. J Cardiovasc Pharmacol. 1992;20 Suppl 6:S15-21.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of January 19, 2019


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CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers


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