481-29-8 trans-Androsterone AKSci J10456
Loading Please Wait...
  J10456    AKSci Reference Standard
, 99% (GC)
Androsterone, Epiandrosterone

CAS Number:481-29-8
MDL Number:MFCD00064134
Min. Purity Spec:99% (GC)
Physical Form (at 20°C):Solid
Melting Point:171-178°C
Optical Rotation:+91° ~ +95°(c=1, MeOH)
Long-Term Storage:Store long-term in a cool, dry place
Not hazardous material


 trans-Androsterone (also known as Epiandrosterone), is a steroid hormone with weak androgenic activity. It is a natural metabolite of dehydroepiandrosterone (DHEA) via the 5a-reductase enzyme. trans-Androsterone is formed in peripheral tissues, from which it is released into the circulation, excreted in the urine, but also found in the sweat and saliva of both male and female humans, as well as a variety of other mammals. trans-Androsterone is only a weak androgen, but it is widely recognized to inhibit the pentose phosphate pathway (PPP) and to decrease intracellular NADPH levels. trans-Androsterone attenuates NO-evoked relaxation of pulmonary artery, although it inhibits angiotensin II- and hypoxia-induced vasoconstriction in isolated lungs and relaxes isolated pulmonary arteries pre-constricted with KCI. trans-Androsterone is currently included as an ingredient in a number of commercial pheromone products.

[1]Gupte SA, Tateyama M, Okada T, Oka M, Ochi R. Epiandrosterone, a metabolite of testosterone precursor, blocks L-type calcium channels of ventricular myocytes and inhibits myocardial contractility. J Mol Cell Cardiol. 2002 Jun;34(6):679-88.
[2] Gupte SA, Rupawalla T, Phillibert D Jr, Wolin MS. NADPH and heme redox modulate pulmonary artery relaxation and guanylate cyclase activation by NO. Am J Physiol. 1999 Dec;277(6 Pt 1):L1124-32.
[3] Gupte SA, Li KX, Okada T, Sato K, Oka M. Inhibitors of pentose phosphate pathway cause vasodilation: involvement of voltage-gated potassium channels. J Pharmacol Exp Ther. 2002. Apr;301(1):299-305.
[4] Dudas B, Hanin I, Rose M, Wulfert E. Protection against inflammatory neurodegeneration and glial cell death by 7beta-hydroxy epiandrosterone, a novel neurosteroid. Neurobiol Dis. 2004 Mar;15(2):262-8



Signal Word

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of June 6, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.

Download SDS Request COA

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise. They are not sold to individuals. Additional restrictions may apply.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.


 APIs and Bioactives >