REVIEW trans-Androsterone (also known as Epiandrosterone), is a steroid hormone with weak androgenic activity. It is a natural metabolite of dehydroepiandrosterone (DHEA) via the 5a-reductase enzyme. trans-Androsterone is formed in peripheral tissues, from which it is released into the circulation, excreted in the urine, but also found in the sweat and saliva of both male and female humans, as well as a variety of other mammals. trans-Androsterone is only a weak androgen, but it is widely recognized to inhibit the pentose phosphate pathway (PPP) and to decrease intracellular NADPH levels. trans-Androsterone attenuates NO-evoked relaxation of pulmonary artery, although it inhibits angiotensin II- and hypoxia-induced vasoconstriction in isolated lungs and relaxes isolated pulmonary arteries pre-constricted with KCI. trans-Androsterone is currently included as an ingredient in a number of commercial pheromone products.
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