76-25-5 Triamcinolone acetonide AKSci J10453
 
 
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  J10453    
Triamcinolone acetonide, 99% (HPLC)
 
9alpha-Fluoro-16alpha-hydroxyprednisolone-16alpha,17alpha-acetonide
Azmacort
IDENTITY
CAS Number:76-25-5
MDL Number:MFCD00056834
MF:C24H31FO6
MW:434.50
EINECS:200-948-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:274-294°C
Optical Rotation:+109° (c=0.75, CHCl3)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 87mg/mL; H2O: <1mg/mL; EtOH: 13mg/mL
Application(s):Glucocorticoid; Immunosuppressive Agent; Anti-Inflammatory Agent
Form:Free Base

REVIEW
 The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. Firstly, however, these glucocorticoids bind to the glucocorticoid receptors which translocate into the nucleus and bind DNA (GRE) and change genetic expression both positively and negatively. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

REFERENCES
[1]Schwartz C, Javvaji S, Feinberg JS (2012). Linear rays of hypopigmentation following intra-articular corticosteroid injection for post-traumatic degenerative joint disease. Dermatol Online J. 18(5):11. PMID 22630581.
[2] Mori H, Rafiq K, Kobara H, Fujihara S, Nishiyama N, Kobayashi M, Himoto T, Haba R, Hagiike M, Izuishi K, Okano K, Suzuki Y, Masaki T (2012). Local steroid injection into the artificial ulcer created by endoscopic submucosal dissection for gastric cancer: prevention of gastric deformity. Endoscopy. 44(7):641-8. PMID 22696191.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H360

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501

Current as of September 4, 2025


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CATEGORIES
 APIs and Bioactives > Steroid Hormones


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