13463-41-7 Zinc pyrithione AKSci J10432
 
 
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  J10432    AKSci Reference Standard
Zinc pyrithione
, >98%, powder
 
Mercaptopyridine N-oxide zinc salt
1-Hydroxypyridine-2-thione zinc




IDENTITY
CAS Number:13463-41-7
MDL Number:MFCD00067336
MF:C10H8N2O2S2Zn
MW:317.69
EINECS:236-671-3
SPECIFICATIONS & PROPERTIES
Purity:>98%, powder
Physical Form:White to off-white to light yellow to beige crystals, powder or solid
Melting Point:263-267°C
Density:1.76g/cm3
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1
Packing Group:II

BIOLOGICAL INFO
Solubility:Soluble in pyridine; Slightly soluble in chloroform, DMF, DMSO

REVIEW

 1-Hydroxypyridine-2-thione zinc is a safe and effective antimicrobial agent, and is best known for its use in treating dandruff and seborrhoeic dermatitis. It also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera. Its other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea, and vitiligo. Its antifungal effect is proposed to derive from its ability to disrupt membrane transport by blocking the proton pump that energizes the transport mechanism. It has been shown that 1-hydroxypyridine-2-thione zinc resulted in a marked decrease in the activities of a variety of independently-regulated transport systems, including those for inorganic sulfate, inorganic phosphate, methylamine (actually, the ammonium permease), choline-O-sulfate, glucose, l-methionine (a specific system), and several hydrophobic l-alpha-amino acids (the general amino acid permease).

REFERENCES
[1]Chandler CJ, Segel IH.Mechanism of the antimicrobial action of pyrithione: effects on membrane transport, ATP levels, and protein synthesis. Antimicrob Agents Chemother. 1978 Jul;14(1):60-8.
[2] Bergbrant IM.Seborrhoeic dermatitis and Pityrosporum yeasts. Curr Top Med Mycol. 1995;6:95-112.
[3] Janniger CK, Schwartz RA. Seborrheic dermatitis.Am Fam Physician. 1995 Jul;52(1):149-55, 159-60.
[4] Faergemann J. Management of seborrheic dermatitis and pityriasis versicolor. Am J Clin Dermatol. 2000 Mar-Apr;1(2):75-80.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301+H331; H318; H410

Precautionary Statements
P261; P264; P270; P271; P273; P280; P301+P310; P304+P340; P305+P351+P338; P310; P321; P330; P391; P403+P233; P405; P501


Current as of May 23, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antibacterials, Fungicides, Dermatology


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