White to off-white to light yellow to beige crystals, powder or solid
Store at room temperature
Soluble in pyridine; Slightly soluble in chloroform, DMF, DMSO
REVIEW 1-Hydroxypyridine-2-thione zinc is a safe and effective antimicrobial agent, and is best known for its use in treating dandruff and seborrhoeic dermatitis. It also has antibacterial properties and is effective against many pathogens from the Streptococcus and Staphylococcus genera. Its other medical applications include treatments of psoriasis, eczema, ringworm, fungus, athletes foot, dry skin, atopic dermatitis, tinea, and vitiligo. Its antifungal effect is proposed to derive from its ability to disrupt membrane transport by blocking the proton pump that energizes the transport mechanism. It has been shown that 1-hydroxypyridine-2-thione zinc resulted in a marked decrease in the activities of a variety of independently-regulated transport systems, including those for inorganic sulfate, inorganic phosphate, methylamine (actually, the ammonium permease), choline-O-sulfate, glucose, l-methionine (a specific system), and several hydrophobic l-alpha-amino acids (the general amino acid permease).
Chandler CJ, Segel IH.Mechanism of the antimicrobial action of pyrithione: effects on membrane transport, ATP levels, and protein synthesis. Antimicrob Agents Chemother. 1978 Jul;14(1):60-8.
Bergbrant IM.Seborrhoeic dermatitis and Pityrosporum yeasts. Curr Top Med Mycol. 1995;6:95-112.