204255-11-8 Osteltamivir phosphate AKSci J10429
 
 
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  J10429    
Osteltamivir phosphate, 99% (HPLC)
 
Tamiflu
IDENTITY
CAS Number:204255-11-8
MDL Number:MFCD08059548
MF:C16H28N2O4.H3PO4
MW:410.40
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:197-212°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Competitive neuraminidase inhibitor

REVIEW
 Oseltamivir phosphate is the first orally active neuraminidase inhibitor antiviral drug approved for human use. It is used to treat influenza A virus and influenza B virus infections. Oseltamivir is a prodrug and is itself not virally effective; however, once in the liver it is hydrolysed to its active metabolite - the free carboxylate of oseltamivir. This free carboxylic acid is a competitive inhibitor of the activity of the viral neuraminidase enzyme upon sialic acid, found on glycoproteins on the surface of normal host cells. By blocking the activity of the enzyme, oseltamivir prevents new viral particles from being released by infected cells.

REFERENCES
[1]Abrecht, Stefan; Karpf, Martin; Trussardi, Rene; Wirz, Beat Process for the preparation of Tamiflu and related 4,5-diaminoshikimic acid derivatives via Diels-Alder cycloaddition Eur. Pat. Appl. (2001), EP 1127872 A1 20010829.
[2] Harrington, Peter J.; Brown, Jack D.; Foderaro, Tommaso; Hughes, Robert C Research and Development of a Second-Generation Process for Oseltamivir Phosphate, Prodrug for a Neuraminidase Inhibitor Organic Process Research & Development (2004), 8(1), 86-91.
[3] Reddy, Bandi Parthasaradhi; Reddy, Kura Rathnakar; Reddy, Rapolu Raji; Reddy, Dasari Muralidhara; Reddy, Kesireddy Subash Chander Process for the preparation of oseltamivir phosphate PCT Int. Appl. (2007), WO 2007060681 A1 20070531.
[4] Kim CU, Chen X, Mendel DB.Neuraminidase inhibitors as anti-influenza virus agents. Antivir Chem Chemother. 1999 Jul;10(4):141-54.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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CATEGORIES
 APIs and Bioactives > Antivirals, Influenza


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