76095-16-4 Enalapril maleate AKSci J10412
 
 
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  J10412    AKSci Reference Standard
Enalapril maleate, >98% (HPLC)
 
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IDENTITY
CAS Number:76095-16-4
MDL Number:MFCD00133304
MF:C20H28N2O5.C4H4O4
MW:492.52
EINECS:278-375-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC, Polarimetry
Physical Form (at 20°C):White to off-white crystalline powder
Melting Point:143-153°C
Optical Rotation:-40.0° - -44.0° (c=1, MeOH)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Sparingly soluble in water and methanol
Application(s):Angiotensin converting enzyme (ACE) inhibitor
Form:Maleate salt

REVIEW
 Enalapril maleate (Vasotec), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Enalaprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

REFERENCES
[1]D.P. Ip and G.S. Brenner, in K. Florey (Editor), Analytical Profiles of Drug Substances, Vol. 16, Aca- demic Press, London, 1987, pp. 207-243.
[2] Lee PH, Conradi R, Shanmugasundaram V (2010). Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorg Med Chem Lett. 20(1):69-73. PMID 19963379.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 29, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > ACE Inhibitors


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