76095-16-4 Enalapril maleate AKSci J10412
 
 
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  J10412    
Enalapril maleate
, >98% (HPLC)
 
Amprace
Bitensil
Cardiovet
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IDENTITY
CAS Number:76095-16-4
MDL Number:MFCD00133304
MF:C20H28N2O5.C4H4O4
MW:492.52
EINECS:278-375-7
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC, Polarimetry
Physical Form:White to off-white crystalline powder
Melting Point:143-153°C
Optical Rotation:-40.0° - -44.0° (c=1, MeOH)
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:Sparingly soluble in water and methanol
Application(s):Angiotensin converting enzyme (ACE) inhibitor
Form:Maleate salt

REVIEW

 Enalapril maleate (Vasotec), the active metabolite of enalapril, competes with angiotensin I for binding at the angiotensin-converting enzyme, blocking the conversion of angiotensin I to angiotensin II. Inhibition of ACE results in decreased plasma angiotensin II. As angiotensin II is a vasoconstrictor and a negative-feedback mediator for renin activity, lower concentrations result in a decrease in blood pressure and stimulation of baroreceptor reflex mechanisms, which leads to decreased vasopressor activity and to decreased aldosterone secretion. Enalaprilat may also act on kininase II, an enzyme identical to ACE that degrades the vasodilator bradykinin.

REFERENCES
[1]D.P. Ip and G.S. Brenner, in K. Florey (Editor), Analytical Profiles of Drug Substances, Vol. 16, Aca- demic Press, London, 1987, pp. 207-243.
[2] Lee PH, Conradi R, Shanmugasundaram V (2010). Development of an in silico model for human skin permeation based on a Franz cell skin permeability assay. Bioorg Med Chem Lett. 20(1):69-73. PMID 19963379.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of January 18, 2019


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CATEGORIES

 APIs and Bioactives > ACE Inhibitors


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