1508-65-2 Oxybutynin HCl AKSci J10411

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J10411 AKSci Reference Standard
Oxybutynin HCl, >98% (HPLC)

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alpha-Phenylcyclohexaneglycolic acid 4-(diethylamino)-2-butynyl ester hydrochloride

IDENTITY
CAS Number:	1508-65-2
MDL Number:	MFCD00072150
MF:	C22H32ClNO3
MW:	393.95

SPECIFICATIONS & PROPERTIES
Purity:	>98% (HPLC)
Spectra:	LCMS, HPLC
Physical Form:	White powder
Melting Point:	125-128°C
Long-Term Storage:	Store at room temperature

BIOLOGICAL INFO
Solubility:	H2O: 50 mg/mL
Application(s):	Anticholinergic
Form:	HCl salt

REVIEW
Oxybutynin exerts a direct antispasmodic effect on smooth muscle and inhibits the muscarinic action of acetylcholine on smooth muscle. No blocking effects occur at skeletal neuromuscular junctions or autonomic ganglia (antinicotinic effects). By inhibiting particularily the M1 and M2 receptors of the bladder, detrusor activity is markedly decreased.

REFERENCES

[1]	Tupker RA, Harmsze AM, Deneer VH: Oxybutynin therapy for generalized hyperhidrosis. Arch Dermatol. 2006 Aug;142(8):1065-6.
[2]	Mijnhout GS, Kloosterman H, Simsek S, Strack van Schijndel RJ, Netelenbos JC: Oxybutynin: dry days for patients with hyperhidrosis. Neth J Med. 2006 Oct;64(9):326-8.
[3]	Schollhammer M, Misery L: Treatment of hyperhidrosis with oxybutynin. Arch Dermatol. 2007 Apr;143(4):544-5.

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