17321-77-6 Clomipramine HCl AKSci J10410
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  J10410    AKSci Reference Standard
Clomipramine HCl
, 99% (HPLC), powder
3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride
Anafranil hydrochloride

CAS Number:17321-77-6
MDL Number:MFCD00069234
Min. Purity Spec:99% (HPLC), powder
Spectra:LCMS, HPLC
Physical Form:White to off-white powder
Melting Point:194-196°C
Long-Term Storage:Store at room temperature
Not hazardous material

Solubility:DMSO: 70mg/mL; H2O: 25mg/mL; EtOH: 70mg/mL 0.1M HCl
Application(s):Serotonin transporter (SERT); Norepinephrine transporter (NET); Dopamine transporter (DAT)
Form:HCl salt


 Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inhibitor of noradrenaline reuptake. α1-receptor blockage and β-down-regulation have been noted and most likely play a role in the short term effects of clomipramine. A blockade of sodium-channels and NDMA-receptors might, as with other tricyclics, account for its effect in chronic pain, in particular the neuropathic type.

[1]Albert U, Aguglia E, Maina G, Bogetto F (November 2002). Venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder: a preliminary single-blind, 12-week, controlled study. J Clin Psychiatry 63 (11): 1004-9. PMID 12444814.
[2] Greist, JH (Jan 1995). Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis. Archives of General Psychiatry. 52 1 (1): 53-60. PMID 7811162.
[3] Millan MJ, Gobert A, Lejeune F, et al. (August 2001). S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. The Journal of Pharmacology and Experimental Therapeutics 298 (2): 565-80. PMID 11454918
[4] Monsma FJ, Shen Y, Ward RP, Hamblin MW, Sibley DR (March 1993). Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular Pharmacology 43 (3): 320-7. PMID 7680751.



Signal Word

Hazard Statements
H302+H312+H332; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P322; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 23, 2021

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.

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 APIs and Bioactives > Dopamine Antagonists, Antidepressants