144060-53-7 Febuxostat AKSci J10392
 
 
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  J10392    AKSci Reference Standard
Febuxostat, >98% (HPLC), powder
 
Adenuric
2-(3-Cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylic acid
IDENTITY
CAS Number:144060-53-7
MDL Number:MFCD00871598
MF:C16H16N2O3S
MW:316.37
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:209-212°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 63mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Gout Suppressant; Non-purine selective xanthine oxidase inhibitor
Form:Free Base

REVIEW
 Febuxostat is a non-purine selective inhibitor of xanthine oxidase. It works by non-competitively blocking the molybdenum pterin center which is the active site on xanthine oxidase. Xanthine oxidase is needed to successively oxidize both hypoxanthine and xanthine to uric acid. Hence, febuxostat inhibits xanthine oxidase, therefore reducing production of uric acid. Febuxostat inhibits both, oxidized as well as reduced form of xanthine oxidase because of which febuxostat cannot be easily displaced from the molybdenum pterin site.

REFERENCES
[1]'Stamp LK, O''Donnell JL, Chapman PT (2007). Emerging therapies in the long-term management of hyperuricaemia and gout. Internal medicine journal 37 (4): 258-66. doi:10.1111/j.1445-5994.2007.01315.x. PMID 17388867.'
[2] Adenuric (febuxostat) receives marketing authorisation in the European Union. Retrieved 2008-05-28.
[3] Uloric Approved for Gout. U.S. News and World Report. Retrieved 2009-02-16.
[4] Becker MA, Schumacher HR, Wortmann RL, et al. (December 2005). Febuxostat compared with allopurinol in patients with hyperuricemia and gout. N. Engl. J. Med. 353 (23): 2450-61. doi:10.1056/NEJMoa050373. PMID 16339094.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 15, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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