28721-07-5 Oxcarbazepine AKSci J10384
 
 
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  J10384    
Oxcarbazepine
, >98% (HPLC)
 
10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide,




IDENTITY
CAS Number:28721-07-5
MDL Number:MFCD00865307
MF:C15H12N2O2
MW:252.27
EINECS:249-188-8
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:LCMS. HPLC
Physical Form:Beige powder
Melting Point:215-216°C
Long-Term Storage:Store at room temperature
UN #:Not hazmat

BIOLOGICAL INFO
Solubility:DMSO: ~9 mg/mL
Application(s):Inhibits the binding of [3H]BTX to sodium channels

REVIEW

 The exact mechanism by which oxcarbazepine exerts its anticonvulsant effect is unknown. It is known that the pharmacological activity of oxcarbazepine occurs primarily through its 10-monohydroxy metabolite (MHD). In vitro studies indicate an MHD-induced blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neuronal membranes, inhibition of repetitive neuronal discharges, and diminution of propagation of synaptic impulses.

REFERENCES
[1]Mazza M, Della Marca G, Di Nicola M, Martinotti G, Pozzi G, Janiri L, Bria P, Mazza S: Oxcarbazepine improves mood in patients with epilepsy. Epilepsy Behav. 2007 May;10(3):397-401. Epub 2007 Feb 14.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of January 18, 2019


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CATEGORIES

 APIs and Bioactives > Anticonvulsants, AChR Antagonists


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