28721-07-5 Oxcarbazepine AKSci J10384
 
 
Loading Please Wait...
  J10384    AKSci Reference Standard
Oxcarbazepine, >98% (HPLC)
 
10,11-Dihydro-10-oxo-5h-dibenz[b,f]azepine-5-carboxamide,
IDENTITY
CAS Number:28721-07-5
MDL Number:MFCD00865307
MF:C15H12N2O2
MW:252.27
EINECS:249-188-8
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Spectra:LCMS. HPLC
Physical Form (at 20°C):Beige powder
Melting Point:215-216°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: ~9 mg/mL
Application(s):Inhibits the binding of [3H]BTX to sodium channels

REVIEW
 The exact mechanism by which oxcarbazepine exerts its anticonvulsant effect is unknown. It is known that the pharmacological activity of oxcarbazepine occurs primarily through its 10-monohydroxy metabolite (MHD). In vitro studies indicate an MHD-induced blockade of voltage-sensitive sodium channels, resulting in stabilization of hyperexcited neuronal membranes, inhibition of repetitive neuronal discharges, and diminution of propagation of synaptic impulses.

REFERENCES
[1]Mazza M, Della Marca G, Di Nicola M, Martinotti G, Pozzi G, Janiri L, Bria P, Mazza S: Oxcarbazepine improves mood in patients with epilepsy. Epilepsy Behav. 2007 May;10(3):397-401. Epub 2007 Feb 14.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 19, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.


CATEGORIES
 APIs and Bioactives > Anticonvulsants, AChR Antagonists


PubChem