82419-36-1 Ofloxacin AKSci J10376
 
 
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  J10376    AKSci Reference Standard
Ofloxacin, >98% (HPLC)
 
Floxin
Tarivid
Oflocet
IDENTITY
CAS Number:82419-36-1
MDL Number:MFCD00226105
MF:C18H20FN3O4
MW:361.37
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:250-257°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 0.4mg/mL
Application(s):Antibiotic; Antimicrobial Agent; Nucleic Acid Synthesis Inhibitor
Form:Free Base

REVIEW
 Ofloxacin acts on DNA gyrase and toposiomerase IV, enzymes which, like human topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.

REFERENCES
[1]Kawahara, S. (December 1998). [Chemotherapeutic agents under study]. Nippon Rinsho 56 (12): 3096-9. PMID 9883617.
[2] Nelson, JM.; Chiller, TM.; Powers, JH.; Angulo, FJ. (Apr 2007). Fluoroquinolone-resistant Campylobacter species and the withdrawal of fluoroquinolones from use in poultry: a public health success story. Clin Infect Dis 44 (7): 977-80. doi:10.1086/512369. PMID 17342653.
[3] Davis, R.; Bryson, H. M. (1994). Levofloxacin. Drugs 47 (4): 677-700. doi:10.2165/00003495-199447040-00008. PMID 7516863.
[4] Blum, A (1991). Ofloxacin-induced acute severe hepatitis. Southern Medical Journal 84 (9): 1158. doi:10.1097/00007611-199109000-00027. PMID 1891746.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
H778Ofloxacin

Current as of October 16, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antibacterials, Quinolones


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