REVIEW Rifaximin is a semisynthetic analog of rifamycin with poor absorptivity. Rifaximin selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by mechanism similar to rifabutin, beta subunit binding.
REFERENCES
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Pecavar V, Blaschitz M, Hufnagl P, Zeinzinger J, Fiedler A, Allerberger F, Maass M, Indra A (2012). High-resolution melting analysis of the single nucleotide polymorphism hot-spot region in the rpoB gene as an indicator of reduced susceptibility to rifaximin in Clostridium difficile. J Med Microbiol. 61(Pt 6):780-5. PMID 22361457.
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Odena G, Miquel M, Serafín A, Galan A, Morillas R, Planas R, Bartol? R (2012). Rifaximin, but not growth factor 1, reduces brain edema in cirrhotic rats. World J Gastroenterol. 18(17):2084-91. PMID 22563196.
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