80621-81-4 Rifaximin AKSci J10371
 
 
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  J10371    
Rifaximin
, 98% (HPLC), powder
 
Rifaxidin
Xifaxan
Rifaximina
more..




IDENTITY
CAS Number:80621-81-4
MDL Number:MFCD00864973
MF:C43H51N3O11
MW:785.88
BRN:3584528
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:218-228°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 47mg/mL; H2O: <1mg/mL; EtOH: 157mg/mL
Application(s):Antibiotic; RNA polymerase inhibitor
Form:Free Base

REVIEW

 Rifaximin is a semisynthetic analog of rifamycin with poor absorptivity. Rifaximin selectively inhibits (E. coli, B subtilis) bacterial DNA-dependent RNA polymerase by mechanism similar to rifabutin, beta subunit binding.

REFERENCES
[1]Pecavar V, Blaschitz M, Hufnagl P, Zeinzinger J, Fiedler A, Allerberger F, Maass M, Indra A (2012). High-resolution melting analysis of the single nucleotide polymorphism hot-spot region in the rpoB gene as an indicator of reduced susceptibility to rifaximin in Clostridium difficile. J Med Microbiol. 61(Pt 6):780-5. PMID 22361457.
[2] Odena G, Miquel M, Serafín A, Galan A, Morillas R, Planas R, Bartol? R (2012). Rifaximin, but not growth factor 1, reduces brain edema in cirrhotic rats. World J Gastroenterol. 18(17):2084-91. PMID 22563196.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of May 14, 2024


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.



CATEGORIES

 APIs and Bioactives > Antibacterials, Rifamycins


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