REVIEW An antifungal medication commonly used in the treatment of fungal infections. The primary mechanism of action of clotrimazole is against the division and growing of fungi. Clotrimazole alters the permeability of the fungal cell wall and inhibits the activity of enzymes within the cell. It specifically inhibits the biosynthesis of ergosterol and other sterols required for cell membrane production. Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase and may alter the metabolism of other drugs.
Martínez A, Carreon T, Iniguez E, Anzellotti A, Sánchez A, Tyan M, Sattler A, Herrera L, Maldonado RA, Sánchez-Delgado RA (2012). Searching for new chemotherapies for tropical diseases: ruthenium-clotrimazole complexes display high in vitro activity against Leishmania major and Trypanosoma cruzi and low toxicity toward normal mammalian cells. J Med Chem. 55(8):3867-77. PMID 22448965.
Sharman M, Lenard Z, Hosgood G, Mansfield C (2012). Clotrimazole and enilconazole distribution within the frontal sinuses and nasal cavity of nine dogs with sinonasal aspergillosis. J Small Anim Pract. 53(3):161-7. PMID 22300493.
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