23593-75-1 Clotrimazole AKSci J10369
 
 
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  J10369    AKSci Reference Standard
Clotrimazole, 99% (HPLC), powder
 
1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
1-(o-Chlorotrityl)imidazole
Canesten
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IDENTITY
CAS Number:23593-75-1
MDL Number:MFCD00057220
MF:C22H17ClN2
MW:344.84
EINECS:245-764-8
BRN:622318
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:144-151°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 11mg/mL; H2O: <1mg/mL; EtOH: 69mg/mL; CHCl3: 50mg/mL
Application(s):Antifungal Agent; 14-alpha Demethylase Inhibitor
Form:Free Base

REVIEW
 An antifungal medication commonly used in the treatment of fungal infections. The primary mechanism of action of clotrimazole is against the division and growing of fungi. Clotrimazole alters the permeability of the fungal cell wall and inhibits the activity of enzymes within the cell. It specifically inhibits the biosynthesis of ergosterol and other sterols required for cell membrane production. Clotrimazole is a potent, specific inhibitor of cytochrome P450 oxidase and may alter the metabolism of other drugs.

REFERENCES
[1]Martínez A, Carreon T, Iniguez E, Anzellotti A, Sánchez A, Tyan M, Sattler A, Herrera L, Maldonado RA, Sánchez-Delgado RA (2012). Searching for new chemotherapies for tropical diseases: ruthenium-clotrimazole complexes display high in vitro activity against Leishmania major and Trypanosoma cruzi and low toxicity toward normal mammalian cells. J Med Chem. 55(8):3867-77. PMID 22448965.
[2] Sharman M, Lenard Z, Hosgood G, Mansfield C (2012). Clotrimazole and enilconazole distribution within the frontal sinuses and nasal cavity of nine dogs with sinonasal aspergillosis. J Small Anim Pract. 53(3):161-7. PMID 22300493.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319

Precautionary Statements
P264; P270; P280; P301+P312; P302+P352; P305+P351+P338; P321; P330; P332+P313; P337+P313; P362; P501

Current as of September 30, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Fungicides


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