106941-25-7 Adefovir AKSci J10364
 
 
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  J10364    AKSci Reference Standard
Adefovir, >98% (HPLC)
 
P-[[2-(6-Amino-9H-purin-9-yl)ethoxy]methyl]phosphonic acid
9-(2-phosphonylmethoxyethyl)adenine
IDENTITY
CAS Number:106941-25-7
MDL Number:MFCD00866943
MF:C8H12N5O4P
MW:273.19
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>250°C
Density:1.88
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:0.1 M NaOH: =5 mg/mL
Application(s):Nucleotide analog reverse transcriptase inhibitor (ntRTI)

REVIEW
 Adefovir is an oral acyclic nucleotide reverse transcriptase inhibitor used in the treatment of chronic hepatitis B and herpes simplex virus infections. It is an analog of adenosine monophosphate. It is phosphorylated to the active metabolite adefovir diphosphate by cellular kinases. Adefovir diphosphate inhibits HBV DNA polymerase by competing with the natural substrate deoxyadenosine triphosphate and by causing DNA chain termination after its incorporation into viral DNA.

REFERENCES
[1]Holy, Antonin; Rosenberg, Ivan Preparation of 9-[(phosphonomethoxy)alkyl]adenines and their use as virucides Eur. Pat. Appl. (1986), EP 206459 A2 19861230.
[2] Holy, Antonin; Rosenberg, Ivan Acyclic nucleotide analogs. Part III. Synthesis of 9-(2-phosphonylmethoxyethyl)adenine and related compounds Collection of Czechoslovak Chemical Communications (1987), 52(11), 2801-9.
[3] Angarano G.Coming therapies: adefovir. Int J Clin Pract Suppl. 1999 Jun;103:39-41.
[4] Daftary MN.Adefovir (Hepsera) for chronic hepatitis B infection. Am Fam Physician. 2003 Dec 15;68(12):2429-30.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of April 26, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antivirals;NNRTIs


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