Cefadroxil Related Compound B, 7-Aminodeacetoxycephalosporanic acid
IDENTITY
CAS Number:
22252-43-3
MDL Number:
MFCD00151456
MF:
C8H10N2O3S
MW:
214.24
EINECS:
247-654-5
BRN:
5273616
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
>98% (HPLC)
Physical Form (at 20°C):
Solid
Melting Point:
230-242°C
Optical Rotation:
+100 - +112° (c=1, 1M HCl)
Long-Term Storage:
Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
REVIEW 7-Aminodeacetoxycephalosporanic acid is produced from penicillin G made by Penicillium chrysogenum involving several polluting chemical steps followed by enzymatic deacylation using penicillin acylase. It is used as a key intermediate in many cephalosporin antibiotics.
Chauvette, Robert R. 7-Acylaminodeacetoxycephalosporanic acid antibiotics S. African (1970), ZA 6804364 19700109.
[3]
Ishimaru, Toshiyasu; Kodama, Yutaka 7-Aminocephalosporanic acid derivatives Ger. Offen. (1972), DE 2151530 A 19720420.
[4]
Takahashi, Takeshi; Kawahara, Kenji; Isono, Masao 7-Amino-3-methyl-3-cephem-4-carboxylic acid and its methyl ester by selective fermentative hydrolysis of 7-acylamines Ger. Offen. (1972), DE 2163791 A 19720720.
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