17692-31-8 Dropropizine AKSci J10343
 
 
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  J10343    
Dropropizine, >99% (HPLC)
 
3-(4-Phenyl-1-piperazinyl)-1,2-propanediol
Dipropizine
IDENTITY
CAS Number:17692-31-8
MDL Number:MFCD00079124
MF:C13H20N2O2
MW:236.31
EINECS:241-683-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:98-108°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:EtOH
Application(s):Antitussive Agent
Form:Free Base

REVIEW
 This nonopioid compound is a racemic cough suppressant or antitussive agent. Dropropizine acts through a peripheral mechanism, mainly involving modulation of sensitive C-fibre activity, with no action in the central nervous system.

REFERENCES
[1]Staack RF, Theobald DS, Maurer HH (2004). Studies on the human metabolism and the toxicologic detection of the cough suppressant dropropizine in urine using gas chromatography-mass spectrometry. Ther Drug Monit. 26(4):441-9. PMID 15257075.
[2] Schildmann EK, Rémi C, Bausewein C (2011). Levodropropizine in the management of cough associated with cancer or nonmalignant chronic disease--a systematic review. J Pain Palliat Care Pharmacother. 25(3):209-18. PMID 21806417.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of December 26, 2024


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CATEGORIES
 APIs and Bioactives > Antitussive


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