25389-94-0 Kanamycin monosulfate AKSci J10342
 
 
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  J10342    AKSci Reference Standard
Kanamycin monosulfate
 
O-3-Amino-3-deoxy-alpha-D-glucopyranosyl-(1->6)-O-[6-amino-6-deoxy-alpha-D-glucopyranosyl-(1->4)]-2-deoxy-D-streptamine Monosulfate




IDENTITY
CAS Number:25389-94-0
MDL Number:MFCD00070253
MF:C18H36N4O11.H2SO4
MW:582.58
EINECS:246-933-9
SPECIFICATIONS & PROPERTIES
Physical Form (at 20°C):Solid
Melting Point:250°C dec. lit.
Optical Rotation:117.5° (c=1, H2O)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Antibiotic

REVIEW

 Aminoglycosides like kanamycin irreversibly bind to specific 30S-subunit proteins and 16S rRNA. Specifically Kanamycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H360

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501


Current as of October 15, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antibacterials, Aminoglycosides


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