427-51-0 Cyproterone acetate AKSci J10331
 
 
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  J10331    AKSci Reference Standard
Cyproterone acetate, 97% (HPLC)
 
6-Chloro-1-beta,2-beta-dihydro-17-hydroxy-3''H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate
Androcur
Cyproterone 17-O-acetate
IDENTITY
CAS Number:427-51-0
MDL Number:MFCD00864671
MF:C24H29ClO4
MW:416.94
EINECS:207-048-3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:97% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:208-215°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Androgen receptor (AR) antagonist

REVIEW
 The direct antiandrogenic effect of cyproterone is blockage of the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In addition, cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of luteinizing hormone resulting in diminished production of testicular testosterone.

REFERENCES
[1]Giorgi EP, Shirley IM, Grant JK, Stewart JC: Androgen dynamics in vitro in the human prostate gland. Effect of cyproterone and cyproterone acetate. Biochem J. 1973 Mar;132(3):465-74.
[2] Pham-Huu-Trung MT, de Smitter N, Bogyo A, Girard F: Effects of cyproterone acetate on adrenal steroidogenesis in vitro. Horm Res. 1984;20(2):108-15.
[3] Stadtler FA, Langner V: The effect of cyproterone and gonadotrophins on the adrenal gland of juvenile and adult rats. A morphological and morphometrical study. Pathol Res Pract. 1985 Mar;179(4-5):493-8.
[4] Honer C, Nam K, Fink C, Marshall P, Ksander G, Chatelain RE, Cornell W, Steele R, Schweitzer R, Schumacher C: Glucocorticoid receptor antagonism by cyproterone acetate and RU486. Mol Pharmacol. 2003 May;63(5):1012-20.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H312+H332; H351

Precautionary Statements
P201; P202; P261; P271; P280; P302+P352; P304+P340; P308+P313; P322; P363; P405; P501

Current as of October 2, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antiandrogens, Steroid Hormones


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