427-51-0 Cyproterone acetate AKSci J10331

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J10331 AKSci Reference Standard
Cyproterone acetate, 97% (HPLC)

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6-Chloro-1-beta,2-beta-dihydro-17-hydroxy-3''H-cyclopropa(1,2)-pregna-1,4,6-triene-3,20-dione acetate

Androcur

Cyproterone 17-O-acetate

IDENTITY
CAS Number:	427-51-0
MDL Number:	MFCD00864671
MF:	C24H29ClO4
MW:	416.94
EINECS:	207-048-3

SPECIFICATIONS & PROPERTIES
Purity:	97% (HPLC)
Spectra:	LCMS, HPLC
Physical Form:	White crystalline powder
Melting Point:	208-215°C
Long-Term Storage:	Store long-term at 2-8°C

BIOLOGICAL INFO
Application(s):	Androgen receptor (AR) antagonist

REVIEW
The direct antiandrogenic effect of cyproterone is blockage of the binding of dihydrotestosterone to the specific receptors in the prostatic carcinoma cell. In addition, cyproterone exerts a negative feed-back on the hypothalamo-pituitary axis, by inhibiting the secretion of luteinizing hormone resulting in diminished production of testicular testosterone.

REFERENCES

[1]	Giorgi EP, Shirley IM, Grant JK, Stewart JC: Androgen dynamics in vitro in the human prostate gland. Effect of cyproterone and cyproterone acetate. Biochem J. 1973 Mar;132(3):465-74.
[2]	Pham-Huu-Trung MT, de Smitter N, Bogyo A, Girard F: Effects of cyproterone acetate on adrenal steroidogenesis in vitro. Horm Res. 1984;20(2):108-15.
[3]	Stadtler FA, Langner V: The effect of cyproterone and gonadotrophins on the adrenal gland of juvenile and adult rats. A morphological and morphometrical study. Pathol Res Pract. 1985 Mar;179(4-5):493-8.
[4]	Honer C, Nam K, Fink C, Marshall P, Ksander G, Chatelain RE, Cornell W, Steele R, Schweitzer R, Schumacher C: Glucocorticoid receptor antagonism by cyproterone acetate and RU486. Mol Pharmacol. 2003 May;63(5):1012-20.