Inhibits viral RNA polymerases, reverse transcriptase, and DNA polymerases through noncompetitive in
REVIEW Foscarnet exerts its antiviral activity by a selective inhibition at the pyrophosphate binding site on virus-specific DNA polymerases at concentrations that do not affect cellular DNA polymerases.
REFERENCES
[1]
Meyer PR, Rutvisuttinunt W, Matsuura SE, So AG, Scott WA (2007). Stable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnet. J. Mol. Biol. 369 (1): 41-54. doi:10.1016/j.jmb.2007.03.006. PMC 1986715. PMID 17400246.
[2]
Meyer PR, Rutvisuttinunt W, Matsuura SE, So AG, Scott WA (May 2007). Stable complexes formed by HIV-1 reverse transcriptase at distinct positions on the primer-template controlled by binding deoxynucleoside triphosphates or foscarnet. J. Mol. Biol. 369 (1): 41-54. doi:10.1016/j.jmb.2007.03.006. PMC 1986715. PMID 17400246.
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