51-48-9 L-Thyroxine AKSci J10324
 
 
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  J10324    AKSci Reference Standard
L-Thyroxine, >98% (HPLC), powder
 
3,3',5,5'-Tetraiodo-L-thyronine
3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine
Levothyroxine
IDENTITY
CAS Number:51-48-9
MDL Number:MFCD00002595
MF:C15H11I4NO4
MW:776.87
EINECS:200-101-1
BRN:2228515
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:223-236°C
Optical Rotation:+21.4° (c=1, in EtOH:1M HCL (2:1))
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 L-Thyroxine is a synthetically prepared levo isomer of thyroxine, the major hormone secreted from the thyroid gland and it acts like the endogenous thyroid hormone thyroxine (T4, a tetra-iodinated tyrosine derivative). L-Thyroxine is used alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor.

REFERENCES
[1]Koch L. Pharmacotherapy: Levothyroxine in the elderly-finding the breaking point. Nat Rev Endocrinol. (2011) Jun 14;7(8): 435.
[2] Andrade C. Levothyroxine in psychiatry: issues related to absorption after oral dosing. J Clin Psychiatry. (2013) Aug;74(8): e744-6.
[3] De Vito P, Incerpi S, Pedersen JZ, Luly P, Davis FB, Davis PJ. Thyroid hormones as modulators of immune activities at the cellular level. Thyroid. (2011) Aug;21(8): 879-90.
[4] 'Salamonczyk, Grzegorz M.; Oza, Vibha B.; Sih, Charles J.A concise synthesis of thyroxine (T4) and 3,5,3''-triiodo-L-thyronine (T3) Tetrahedron Letters (1997), 38(40), 6965-6968.'

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of June 7, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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