51-48-9 L-Thyroxine AKSci J10324
 
 
Loading Please Wait...
  J10324    AKSci Reference Standard
L-Thyroxine
, >98% (HPLC), powder
 
3,3',5,5'-Tetraiodo-L-thyronine
3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine
Levothyroxine




IDENTITY
CAS Number:51-48-9
MDL Number:MFCD00002595
MF:C15H11I4NO4
MW:776.87
EINECS:200-101-1
BRN:2228515
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC), powder
Spectra:NMR, LCMS, FT-IR, HPLC, Polarimetry
Physical Form:White to beige powder
Melting Point:223-236°C
Optical Rotation:+21.4° (c=1, in EtOH:1M HCL (2:1))
Long-Term Storage:Store at room temperature

REVIEW

 L-Thyroxine is a synthetically prepared levo isomer of thyroxine, the major hormone secreted from the thyroid gland and it acts like the endogenous thyroid hormone thyroxine (T4, a tetra-iodinated tyrosine derivative). L-Thyroxine is used alone or in combination with antithyroid agents to treat hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor.

REFERENCES
[1]Koch L. Pharmacotherapy: Levothyroxine in the elderly-finding the breaking point. Nat Rev Endocrinol. (2011) Jun 14;7(8): 435.
[2] Andrade C. Levothyroxine in psychiatry: issues related to absorption after oral dosing. J Clin Psychiatry. (2013) Aug;74(8): e744-6.
[3] De Vito P, Incerpi S, Pedersen JZ, Luly P, Davis FB, Davis PJ. Thyroid hormones as modulators of immune activities at the cellular level. Thyroid. (2011) Aug;21(8): 879-90.
[4] 'Salamonczyk, Grzegorz M.; Oza, Vibha B.; Sih, Charles J.A concise synthesis of thyroxine (T4) and 3,5,3''-triiodo-L-thyronine (T3) Tetrahedron Letters (1997), 38(40), 6965-6968.'

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 9, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use. Not for human use. AK Scientific, Inc. does not sell to individuals. If you are a first-time customer, please email for review at least two official business documents issued by your local jurisdiction, state/province, or country.


CATEGORIES

 APIs and Bioactives >


PubChem