34381-68-5 Acebutolol hydrochloride AKSci J10323
 
 
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  J10323    AKSci Reference Standard
Acebutolol hydrochloride, >98% (HPLC)
 
N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide hydrochloride
IDENTITY
CAS Number:34381-68-5
MDL Number:MFCD00078860
MF:C18H29ClN2O4
MW:372.89
EINECS:251-980-3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Spectra:NMR, HPLC
Physical Form (at 20°C):White to off-white crystalline powder
Melting Point:141-145°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):beta-adrenergic antagonist

REVIEW
 Acebutolol is a selective β1-receptor antagonist used for the treatment of hypertension. It blocks the activation of β1-receptors by epinephrine, which would increases heart rate and blood pressure. Beta blockers also prevent the release of renin, a hormone secreted by the kidneys which leads to constriction of blood vessels.

REFERENCES
[1]Wooldridge, K. R. H New cardioselective beta-adrenoceptor blocking agent Experientia (1972), 28(12), 1404.
[2] Basil, B.; Clark, J. R.; Coffee, E. C. J.; Jordan, R.; Loveless, A. H.; Pain, D. L.; Wooldridge, K. R. H. New series of cardioselective adrenergic beta-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols Journal of Medicinal Chemistry (1976), 19(3), 399-402.
[3] De Bono G, Kaye CM, Roland E, Summers AJ.Acebutolol: ten years of experience. Am Heart J. 1985 May;109(5 Pt 2):1211-3.
[4] Singh BN, Thoden WR, Ward A. Acebutolol. A review of its pharmacological properties and therapeutic efficacy in hypertension, angina pectoris and arrhythmia. Drugs. 1985 Jun;29(6):531-69.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H312+H332

Precautionary Statements
P261; P271; P280; P302+P352; P304+P340; P312; P322; P363; P501

Current as of January 27, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Beta Blockers


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