REVIEW Acebutolol is a selective β1-receptor antagonist used for the treatment of hypertension. It blocks the activation of β1-receptors by epinephrine, which would increases heart rate and blood pressure. Beta blockers also prevent the release of renin, a hormone secreted by the kidneys which leads to constriction of blood vessels.
REFERENCES
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Wooldridge, K. R. H New cardioselective beta-adrenoceptor blocking agent Experientia (1972), 28(12), 1404.
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Basil, B.; Clark, J. R.; Coffee, E. C. J.; Jordan, R.; Loveless, A. H.; Pain, D. L.; Wooldridge, K. R. H. New series of cardioselective adrenergic beta-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols Journal of Medicinal Chemistry (1976), 19(3), 399-402.
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De Bono G, Kaye CM, Roland E, Summers AJ.Acebutolol: ten years of experience. Am Heart J. 1985 May;109(5 Pt 2):1211-3.
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Singh BN, Thoden WR, Ward A. Acebutolol. A review of its pharmacological properties and therapeutic efficacy in hypertension, angina pectoris and arrhythmia. Drugs. 1985 Jun;29(6):531-69.
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