34381-68-5, 37517-30-9 Acebutolol hydrochloride AKSci J10323
 
 
Loading Please Wait...
  J10323    AKSci Reference Standard
Acebutolol hydrochloride
, >98% (HPLC)
 
N-(3-Acetyl-4-[2-hydroxy-3-(isopropylamino)propoxy]phenyl)butanamide hydrochloride




IDENTITY
CAS Number:34381-68-5, 37517-30-9
MDL Number:MFCD00078860
MF:C18H29ClN2O4
MW:372.89
EINECS:251-980-3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:141-145°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):beta-adrenergic antagonist

REVIEW

 Acebutolol is a selective β1-receptor antagonist used for the treatment of hypertension. It blocks the activation of β1-receptors by epinephrine, which would increases heart rate and blood pressure. Beta blockers also prevent the release of renin, a hormone secreted by the kidneys which leads to constriction of blood vessels.

REFERENCES
[1]Wooldridge, K. R. H New cardioselective beta-adrenoceptor blocking agent Experientia (1972), 28(12), 1404.
[2] Basil, B.; Clark, J. R.; Coffee, E. C. J.; Jordan, R.; Loveless, A. H.; Pain, D. L.; Wooldridge, K. R. H. New series of cardioselective adrenergic beta-receptor blocking compounds. 1-(2-Acyl-4-acylaminophenoxy)-3-isopropylaminopropan-2-ols Journal of Medicinal Chemistry (1976), 19(3), 399-402.
[3] De Bono G, Kaye CM, Roland E, Summers AJ.Acebutolol: ten years of experience. Am Heart J. 1985 May;109(5 Pt 2):1211-3.
[4] Singh BN, Thoden WR, Ward A. Acebutolol. A review of its pharmacological properties and therapeutic efficacy in hypertension, angina pectoris and arrhythmia. Drugs. 1985 Jun;29(6):531-69.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H312+H332

Precautionary Statements
P261; P271; P280; P302+P352; P304+P340; P312; P322; P363; P501


Current as of October 2, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

⚠️
These chemical products are for research and development use only. They are not for diagnostic, therapeutic, cosmetic, or human and animal uses. They are not sold to individuals. Additional restrictions may apply.
New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.


CATEGORIES

 APIs and Bioactives > Beta Blockers


PubChem
  @PubMed