32780-64-6 Labetalol HCl AKSci J10319
 
 
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  J10319    AKSci Reference Standard
Labetalol HCl
, 99% (HPLC)
 
Amipress
Presdate
Pressalolo
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IDENTITY
CAS Number:32780-64-6
MDL Number:MFCD00057663
MF:C19H25ClN2O3
MW:364.87
EINECS:251-211-1
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:LCMS, HPLC
Physical Form:White powder
Melting Point:190-193°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:Soluble in water and ethanol
Application(s):Blocker of both alpha- and beta-adrenergic receptors
Form:HCl salt

REVIEW

 Labetalol HCl combines both selective, competitive, alpha-1-adrenergic blocking and nonselective, competitive, beta-adrenergic blocking activity in a single substance. In man, the ratios of alpha- to beta- blockade have been estimated to be approximately 1:3 and 1:7 following oral and intravenous (IV) administration, respectively. The principal physiologic action of labetalol is to competitively block adrenergic stimulation of β-receptors within the myocardium (β1-receptors) and within bronchial and vascular smooth muscle (β2-receptors), and α1-receptors within vascular smooth muscle. This causes a decrease in systemic arterial blood pressure and systemic vascular resistance without a substantial reduction in resting heart rate, cardiac output, or stroke volume, apparently because of its combined α- and β-adrenergic blocking activity.

REFERENCES
[1]Fahed S, Grum DF, Papadimos TJ (2008). Labetalol infusion for refractory hypertension causing severe hypotension and bradycardia: an issue of patient safety. Patient Saf Surg 2: 13. doi:10.1186/1754-9493-2-13. PMC 2429901. PMID 18505576.
[2] Riva E, Mennini T, Latini R (December 1991). The alpha- and beta-adrenoceptor blocking activities of labetalol and its RR-SR (50:50) stereoisomers. Br. J. Pharmacol. 104 (4): 823-8. PMC 1908821. PMID 1687367.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 7, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Alpha Blockers


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