REVIEW Raltegravir is an antiretroviral drug used to treat HIV infection. It is the first integrase inhibitor to receive approval. HIV-1 integrase is a key enzyme in the replication mechanism of retroviruses, responsible for transfer of virally-encoded DNA into the host chromosome. Since integrase has no equivalent in the host cell, integrase inhibitors have a high therapeutic index. Research on human cytomegalovirus (HCMV) terminase proteins demonstrated that raltegravir may block viral replication of the herpesviruses.
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Summa, Vincenzo; Journal of Medicinal Chemistry 2008, V51(18), P5843-5855
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Humphrey, Guy R.; Organic Process Research & Development 2011, V15(1), P73-83
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