145-13-1 Pregnenolone AKSci J10307
 
 
Loading Please Wait...
  J10307    
Pregnenolone, 99% (HPLC), powder
 
5-Pregnen-3beta-ol-20-one
3beta-Hydroxy-5-pregnen-20-one
IDENTITY
CAS Number:145-13-1
MDL Number:MFCD00003628
MF:C21H32O2
MW:316.48
EINECS:205-647-4
BRN:2059026
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:187-195°C
Optical Rotation:+26.0° - +32.0° (c=1, EtOH)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 22mg/mL; H2O: insoluble; EtOH: 22mg/mL
Application(s):Inhibition of M1 receptor- and M3 receptor-mediated currents

REVIEW
 Pregnenolone is an endogenous steroid hormone involved in the steroidogenesis of progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. As such it is a prohormone, though it also has biological effects of its own, behaving namely as a neuroactive steroid in its own right with potent anxiolytic effects. Pregnenolone is also being considered as a potential treatment for schizophrenia.

REFERENCES
[1]Miller, Walter L.; Auchus, Richard J. The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocrine Reviews. (2011) 32(1): 81-151.
[2] Schuele, C.; Eser, D.; Baghai, T. C.; Nothdurfter, C.; Kessler, J. S.; Rupprecht, R. Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs? Neuroscience (Amsterdam, Netherlands). (2011) 191: 55-77.
[3] Marx, C. E.; Bradford, D. W.; Hamer, R. M.; Naylor, J. C.; Allen, T. B.; Lieberman, J. A.; Strauss, J. L.; Kilts, J. D. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience (Amsterdam, Netherlands). (2011) 191: 78-90.
[4] Petit, Andre; Pesez, Maurice Transesterification in the steroid series Bulletin de la Societe Chimique de France (1947), 705-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of July 4, 2025


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Steroid Hormones


PubChem