Inhibition of M1 receptor- and M3 receptor-mediated currents
REVIEW Pregnenolone is an endogenous steroid hormone involved in the steroidogenesis of progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. As such it is a prohormone, though it also has biological effects of its own, behaving namely as a neuroactive steroid in its own right with potent anxiolytic effects. Pregnenolone is also being considered as a potential treatment for schizophrenia.
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Miller, Walter L.; Auchus, Richard J. The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocrine Reviews. (2011) 32(1): 81-151.
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Schuele, C.; Eser, D.; Baghai, T. C.; Nothdurfter, C.; Kessler, J. S.; Rupprecht, R. Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs? Neuroscience (Amsterdam, Netherlands). (2011) 191: 55-77.
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Marx, C. E.; Bradford, D. W.; Hamer, R. M.; Naylor, J. C.; Allen, T. B.; Lieberman, J. A.; Strauss, J. L.; Kilts, J. D. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience (Amsterdam, Netherlands). (2011) 191: 78-90.
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