145-13-1 Pregnenolone AKSci J10307
 
 
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  J10307    
Pregnenolone
, 99% (HPLC)
 
5-Pregnen-3beta-ol-20-one
3beta-Hydroxy-5-pregnen-20-one




IDENTITY
CAS Number:145-13-1
MDL Number:MFCD00003628
MF:C21H32O2
MW:316.48
EINECS:205-647-4
BRN:2059026
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:FT-IR, LCMS, HPLC, Polarimetry
Physical Form:White to off-white powder
Melting Point:187-195°C
Optical Rotation:+26.0° - +32.0° (c=1, EtOH)
Long-Term Storage:Store at room temperature
UN #:Not hazmat

BIOLOGICAL INFO
Solubility:DMSO: 22mg/mL; H2O: insoluble; EtOH: 22mg/mL
Application(s):Inhibition of M1 receptor- and M3 receptor-mediated currents

REVIEW

 Pregnenolone is an endogenous steroid hormone involved in the steroidogenesis of progestogens, mineralocorticoids, glucocorticoids, androgens, and estrogens, as well as the neuroactive steroids. As such it is a prohormone, though it also has biological effects of its own, behaving namely as a neuroactive steroid in its own right with potent anxiolytic effects. Pregnenolone is also being considered as a potential treatment for schizophrenia.

REFERENCES
[1]Miller, Walter L.; Auchus, Richard J. The molecular biology, biochemistry, and physiology of human steroidogenesis and its disorders. Endocrine Reviews. (2011) 32(1): 81-151.
[2] Schuele, C.; Eser, D.; Baghai, T. C.; Nothdurfter, C.; Kessler, J. S.; Rupprecht, R. Neuroactive steroids in affective disorders: target for novel antidepressant or anxiolytic drugs? Neuroscience (Amsterdam, Netherlands). (2011) 191: 55-77.
[3] Marx, C. E.; Bradford, D. W.; Hamer, R. M.; Naylor, J. C.; Allen, T. B.; Lieberman, J. A.; Strauss, J. L.; Kilts, J. D. Pregnenolone as a novel therapeutic candidate in schizophrenia: emerging preclinical and clinical evidence. Neuroscience (Amsterdam, Netherlands). (2011) 191: 78-90.
[4] Petit, Andre; Pesez, Maurice Transesterification in the steroid series Bulletin de la Societe Chimique de France (1947), 705-8.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of December 14, 2018


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CATEGORIES

 APIs and Bioactives > Steroid Hormones


PubChem