4205-91-8 Clonidine hydrochloride AKSci J10306
 
 
Loading Please Wait...
  J10306    AKSci Reference Standard
Clonidine hydrochloride
, >98% (HPLC)
 
2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride
Catapres




IDENTITY
CAS Number:4205-91-8
MDL Number:MFCD00036705
MF:C9H9Cl2N3.HCl
MW:266.55
EINECS:224-121-5
BRN:4163525
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC)
Spectra:LCMS, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:>300°C
Long-Term Storage:Store long-term at 2-8°C
UN #:UN2811
Hazard Class:6.1
Packing Group:I

BIOLOGICAL INFO
Solubility:H2O: 50mg/mL
Application(s):alpha-2 adrenergic agonist
Form:HCl salt

REVIEW

 Clonidine treats high blood pressure by stimulating a2 receptors in the brain, which decreases cardiac output and peripheral vascular resistance, lowering blood pressure. It has specificity towards the presynaptic a2 receptors in the vasomotor center in the brainstem. This binding decreases presynaptic calcium levels, and inhibits the release of norepinephrine (NE). The net effect is a decrease in sympathetic tone. It has also been proposed that the antihypertensive effect of clonidine is due to agonism on the I1-receptor (imidazoline receptor), which mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure.

REFERENCES
[1]Greene N, Fisk L, Naven RT, Note RR, Patel ML, Pelletier DJ (2010). Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 19;23(7):1215-22. PMID 20553011.
[2] Reitz, DJ; Piletz, JE (1997). The imidazoline receptor in control of blood pressure by clonidine and allied drugs. American Journal of Physiology 273 (5): R1569-R1571.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H330

Precautionary Statements
P260; P264; P270; P271; P284; P301+P310; P304+P340; P310; P320; P330; P403+P233; P405; P501


Current as of October 20, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS

For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Adrenergic Agonists


PubChem