4205-91-8 Clonidine hydrochloride AKSci J10306
 
 
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  J10306    AKSci Reference Standard
Clonidine hydrochloride, >98% (HPLC)
 
2-(2,6-Dichloroanilino)-2-imidazoline hydrochloride
Catapres
IDENTITY
CAS Number:4205-91-8
MDL Number:MFCD00036705
MF:C9H9Cl2N3.HCl
MW:266.55
EINECS:224-121-5
BRN:4163525
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>300°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply depending on the amount ordered, as indicated in the list of package sizes.

BIOLOGICAL INFO
Solubility:H2O: 50mg/mL
Application(s):alpha-2 adrenergic agonist
Form:HCl salt

REVIEW
 Clonidine treats high blood pressure by stimulating a2 receptors in the brain, which decreases cardiac output and peripheral vascular resistance, lowering blood pressure. It has specificity towards the presynaptic a2 receptors in the vasomotor center in the brainstem. This binding decreases presynaptic calcium levels, and inhibits the release of norepinephrine (NE). The net effect is a decrease in sympathetic tone. It has also been proposed that the antihypertensive effect of clonidine is due to agonism on the I1-receptor (imidazoline receptor), which mediates the sympatho-inhibitory actions of imidazolines to lower blood pressure.

REFERENCES
[1]Greene N, Fisk L, Naven RT, Note RR, Patel ML, Pelletier DJ (2010). Developing structure-activity relationships for the prediction of hepatotoxicity. Chem Res Toxicol. 19;23(7):1215-22. PMID 20553011.
[2] Reitz, DJ; Piletz, JE (1997). The imidazoline receptor in control of blood pressure by clonidine and allied drugs. American Journal of Physiology 273 (5): R1569-R1571.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H330

Precautionary Statements
P260; P264; P270; P271; P284; P301+P310; P304+P340; P310; P320; P330; P403+P233; P405; P501

Current as of March 29, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Adrenergic Agonists


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