REVIEW Guaifenesin is thought to act as an expectorant by increasing the volume and reducing the viscosity of secretions in the trachea and bronchi. It also stimulates the flow of respiratory tract secretions, allowing ciliary movement to carry the loosened secretions upward toward the pharynx.
REFERENCES
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Hu Z, Zou Q, Tian J, Sun L, Zhang Z (2011). Simultaneous determination of codeine, ephedrine, guaiphenesin and chlorpheniramine in beagle dog plasma using high performance liquid chromatography coupled with tandem mass spectrometric detection: application to a bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci. 879(32):3937-42. PMID 22119507.
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Seagrave J, Albrecht H, Park YS, Rubin B, Solomon G, Kim KC (2011). Effect of guaifenesin on mucin production, rheology, and mucociliary transport in differentiated human airway epithelial cells. Exp Lung Res. 37(10):606-14. PMID 22044398.
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