77883-43-3 Doxazosin mesylate AKSci J10294
 
 
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  J10294    
Doxazosin mesylate
, 99% (HPLC), powder
 
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-[4-(1,4-benzodioxan-2-yl)carpiperazin-1-yl)]-6,7-dimethoxyquinazoline mesylate
Cardura
Carduran




IDENTITY
CAS Number:77883-43-3
MDL Number:MFCD00216023
MF:C24H29N5O8S
MW:547.58
BRN:7791129
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC), powder
Spectra:18633 CM
Physical Form:White to off-white to pale yellow crystalline powder
Melting Point:248-255°C
Boiling Point:718°C
Density:1.371
Long-Term Storage:Store long-term at -20°C
UN #:Not hazmat

BIOLOGICAL INFO
Solubility:DMSO: 15mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):alpha-1-adrenergic receptor antagonist
Form:Mesylate salt

REVIEW

 An alpha-1 selective alpha blocker used to treat high blood pressure and urinary retention associated with benign prostatic hyperplasia (BPH). The drug inhibits the binding of norepinephrine (released from sympathetic nerve terminals) to the alpha-1 receptors on the membrane of vascular smooth muscle cells. The primary effect of this inhibition is relaxed vascular smooth muscle tone (vasodilation), which decreases peripheral vascular resistance, leading to decreased blood pressure.

REFERENCES
[1]Du H, Ren J, Wang S, He L (2011). Cell membrane chromatography competitive binding analysis for characterization of alpha 1A adrenoreceptor binding interactions. Anal Bioanal Chem. 400(10):3625-33. PMID 21544540.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of January 19, 2019


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CATEGORIES

 APIs and Bioactives > Alpha Blockers


PubChem