144701-48-4 Telmisartan AKSci J10282
 
 
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  J10282    AKSci Reference Standard
Telmisartan
, >98% (HPLC), powder
 



IDENTITY
CAS Number:144701-48-4
MDL Number:MFCD00918125
MF:C33H30N4O2
MW:514.62
BRN:6624054
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC), powder
Spectra:LCMS, FT-IR, HPLC
Physical Form:White to off-white powder or solid
Melting Point:265-277°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: >5mg/mL (60 °C); H2O: insoluble
Application(s):Angiotensin II receptor antagonist (ARB)
Form:Free Base

REVIEW

 Telmisartan interferes with the binding of angiotensin II to the angiotensin II AT1-receptor by binding reversibly and selectively to the receptors in vascular smooth muscle and the adrenal gland. As angiotensin II is a vasoconstrictor, which also stimulates the synthesis and release of aldosterone, blockage of its effects results in decreases in systemic vascular resistance. Telmisartan does not inhibit the angiotensin converting enzyme, other hormone receptors, or ion channels. Studies also suggest that telmisartan is a partial agonist of PPAR-gamma, which is an established target for antidiabetic drugs. This suggests that telmisartan can improve carbohydrate and lipid metabolism, as well as control insulin resistance without causing the side effects that are associated with full PPAR-gamma activators.

REFERENCES
[1]Sharpe M, Jarvis B, Goa KL: Telmisartan: a review of its use in hypertension. Drugs. 2001;61(10):1501-29.
[2] Smith DH: Treatment of hypertension with an angiotensin II-receptor antagonist compared with an angiotensin-converting enzyme inhibitor: a review of clinical studies of telmisartan and enalapril. Clin Ther. 2002 Oct;24(10):1484-501.
[3] Kumar AS, Ghosh S, Mehta GN: Efficient and improved synthesis of Telmisartan. Beilstein J Org Chem. 2010 Mar 11;6:25.
[4] Galzerano D, Capogrosso C, Di Michele S, Galzerano A, Paparello P, Lama D, Gaudio C: New standards in hypertension and cardiovascular risk management: focus on telmisartan. Vasc Health Risk Manag. 2010 Mar 24;6:113-33.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of June 25, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Angiotensin Receptor Blockers


PubChem