61177-45-5 Clavulanate potassium, microcrystalline cellulose(AVICEL) 1:1 as stabilizer AKSci J10279
 
 
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  J10279    
Clavulanate potassium, microcrystalline cellulose(AVICEL) 1:1 as stabilizer, >98% (HPLC)
 
Potassium clavulanate
Clavulanic acid
Amonate
IDENTITY
CAS Number:61177-45-5
MDL Number:MFCD01710901
MF:C8H8KNO5
MW:237.25
EINECS:262-640-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>300°C
Long-Term Storage:Store long-term at -20°C
Note:Microcrystalline Cellulose(AVICEL) 1:1 as stabilizer
DOT/IATA TRANSPORT INFORMATION
UN #:UN1325
Hazard Class:4.1; Flammable Solid
Packing Group:II
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Application(s):Suicide inhibitor of bacterial beta-lactamase enzymes

REVIEW
 Clavulanic acid competitively and irreversibly inhibits a wide variety of beta-lactamases, commonly found in microorganisms resistant to penicillins and cephalosporins. Binding and irreversibly inhibiting the beta-lactamase results in a restauration of the antimicrobial activity of beta-lactam antibiotics against lactamase-secreting-resistant bacteria. By inactivating beta-lactamase (the bacterial resistance protein), the accompanying penicillin/cephalosporin drugs may be made more potent as well.

REFERENCES
[1]Arulanantham H, Kershaw NJ, Hewitson KS, Hughes CE, Thirkettle JE, Schofield CJ (January 2006). ORF17 from the clavulanic acid biosynthesis gene cluster catalyzes the ATP-dependent formation of N-glycyl-clavaminic acid. J. Biol. Chem. 281 (1): 279-87. doi:10.1074/jbc.M507711200. PMID 16251194.
[2] Tahlan K, Park HU, Wong A, Beatty PH, Jensen SE (March 2004). Two sets of paralogous genes encode the enzymes involved in the early stages of clavulanic acid and clavam metabolite biosynthesis in Streptomyces clavuligerus. Antimicrob. Agents Chemother. 48 (3): 930-9. doi:10.1128/AAC.48.3.930-939.2004. PMC 353097. PMID 14982786.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H228; H252; H261; H317; H319; H334

Precautionary Statements
P210; P231+P232; P235+P410; P240; P241; P261; P264; P272; P280; P285; P302+P352; P304+P341; P305+P351+P338; P333+P313; P337+P313; P342+P311; P363; P370+P378; P402+P404; P407; P413; P420; P501

Current as of October 15, 2024


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CATEGORIES
 APIs and Bioactives > Antibacterials


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