78110-38-0 Aztreonam AKSci J10266
 
 
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  J10266    AKSci Reference Standard
Aztreonam
, >98% (HPLC), powder
 
Monobactam
SQ 26776
Squibb 26776
more..




IDENTITY
CAS Number:78110-38-0
MDL Number:MFCD00072145
MF:C13H17N5O8S2
MW:435.43
EINECS:278-839-9
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:220°C (dec.)
Optical Rotation:-26° - -32° (c=0.5, H2O)
Density:1.83
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 81mg/mL; H2O: 11mg/mL; EtOH: <1mg/mL
Application(s):Antibiotic
Form:Free Base

REVIEW

 A synthetic monocyclic beta-lactam antibiotic (a monobactam), with the nucleus based on a simpler monobactam isolated from Chromobacterium violaceum. Aztreonam inhibits mucopeptide synthesis in the bacterial cell wall, thereby blocking peptidoglycan crosslinking. It has a very high affinity for penicillin-binding protein 3 (PBP-3) and mild affinity for PBP-1a. Aztreonam binds the penicillin-binding proteins of gram-positive and anaerobic bacteria very poorly and is largely ineffective against them.

REFERENCES
[1]Drusano GL(2012). Early endpoints for acute bacterial skin and skin structure infections. Antimicrob Agents Chemother. 256(5):2221-2. PMID 22314521.
[2] Brown MF, Reilly U, Abramite JA, Arcari JT, Oliver R, Barham RA, Che Y, Chen JM, Collantes EM, Chung SW, Desbonnet C, Doty J, Doroski M, Engtrakul JJ, Harris TM, Huband M, Knafels JD, Leach KL, Liu S, Marfat A, Marra A, McElroy E, Melnick M, Menard CA, Montgomery JI, Mullins L, Noe MC, O'Donnell J, Penzien J, Plummer MS, Price LM, Shanmugasundaram V, Thoma C, Uccello DP, Warmus JS, Wishka DG (2012). Potent inhibitors of LpxC for the treatment of Gram-negative infections. J Med Chem. 55(2):914-23. PMID 22175825.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of October 16, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Antibacterials


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