747-36-4 Hydroxychloroquine sulfate AKSci J10260
 
 
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  J10260    AKSci Reference Standard
Hydroxychloroquine sulfate
, >98% (HPLC), powder
 
7-Chloro-4-[4-(N-ethyl-N-b-hydroxyethylamino)-1-methylbutylamino]quinoline sulfate




IDENTITY
CAS Number:747-36-4
MDL Number:MFCD00078203
MF:C18H28ClN3O5S
MW:433.95
EINECS:212-019-3
BRN:7242072
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC), powder
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to off-white to light yellow crystalline powder
Melting Point:240-251°C
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:H2O: >20mg/mL

REVIEW

 Although the exact mechanism of action is unknown, it may be based on ability of hydroxychloroquine to bind to and alter DNA. Hydroxychloroquine has also has been found to be taken up into the acidic food vacuoles of the parasite in the erythrocyte. This increases the pH of the acid vesicles, interfering with vesicle functions and possibly inhibiting phospholipid metabolism. In suppressive treatment, hydroxychloroquine inhibits the erythrocytic stage of development of plasmodia. In acute attacks of malaria, it interrupts erythrocytic schizogony of the parasite. Its ability to concentrate in parasitized erythrocytes may account for their selective toxicity against the erythrocytic stages of plasmodial infection. As an antirheumatic, hydroxychloroquine is thought to act as a mild immunosuppressant, inhibiting the production of rheumatoid factor and acute phase reactants. It also accumulates in white blood cells, stabilizing lysosomal membranes and inhibiting the activity of many enzymes, including collagenase and the proteases that cause cartilage breakdown.

REFERENCES
[1]Semeniuk, Agata; Journal of Chemical Crystallography 2008, V38(5), P333-338.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302; H319

Precautionary Statements
P264; P270; P280; P301+P312; P305+P351+P338; P330; P337+P313; P501


Current as of April 4, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antimalarials


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