REVIEW Triclocarban is a substance with antibacterial and antifungal properties that is used in disinfectants, soaps and other household products. The mechanism of action involves disruption of cellular membranes, and the chemical may also involve inhibition of the enzyme enoyl-acyl carrier protein reductase (ENR). This enzyme is absent in humans but is essential in building cell membranes of many bacteria and fungi.
REFERENCES
[1]
Herber, John F.. Halogenated carbanilides U.S. (1967), US 3320313 19670516.
[2]
McDonnell G, Russell AD. Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev. 1999 Jan;12(1):147-79.
[3]
Chen J, Ahn KC, Gee NA, Ahmed MI, Duleba AJ, Zhao L, Gee SJ, Hammock BD, Lasley BL.Triclocarban enhances testosterone action: a new type of endocrine disruptor? Endocrinology. 2008 Mar;149(3):1173-9.
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Witorsch RJ, Thomas JA. Personal care products and endocrine disruption: A critical review of the literature. Crit Rev Toxicol. 2010 Nov;40 Suppl 3:1-30.
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