43210-67-9 Fenbendazole AKSci J10252
 
 
Loading Please Wait...
  J10252    
Fenbendazole, >98% (HPLC), powder
 
Methyl 5-(phenylthio)-2-benzimidazolecarbamate
[5-(Phenylthio)benzimidazol-2-yl]carbamic acid methyl ester
Panacur
IDENTITY
CAS Number:43210-67-9
MDL Number:MFCD00144301
MF:C15H13N3O2S
MW:299.35
EINECS:256-145-7
BRN:759077
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:227-233°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 4mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Antinematodal Agent
Form:Free Base

REVIEW
 Fenbendazole is a broad-spectrum benzimidazole anthelmintic against gastrointestinal parasites including giardia, roundworms, hookworms, whipworms, Taenia tapeworms, pinworms, aelurostrongylus, paragonimiasis, strongyles and strongyloides. It can be administered to sheep, cattle, horses, fish, dogs, cats, rabbits and seals. Its mode of action is to bind to beta-tubulin and prevent the polymerization of microtubules , impairing intracellular transport mechanisms and interfering with protein synthesis.

REFERENCES
[1]Loewe, Heinz; Urbanietz, Josef; Kirsch, Reinhard; Duewel, Dieter Anthelmintic 5-aryloxy-2-carbalkoxyaminobenzimidazoles Ger. Offen. (1975), DE 2332486 A1 19750327.
[2] Loewe, Heinz; Urbanietz, Josef; Kirsch, Reinhard; Duewel, Dieter 2-(Alkoxycarbonylamino)benzimidazole-5(6)-yl phenyl ether antihelminthic Ger.Offen. (1975), DE 2332343 A1 19750116.
[3] Gardner CR, Mishin V, Laskin JD, Laskin DL (2012). Exacerbation of acetaminophen hepatotoxicity by the anthelmentic drug fenbendazole. Toxicol Sci. 125(2):607-12. PMID 22048645.
[4] Lyons ET, Tolliver SC, Kuzmina TA, Collins SS (2011). Further evaluation in field tests of the activity of three anthelmintics (fenbendazole, oxibendazole, and pyrantel pamoate) against the ascarid Parascaris equorum in horse foals on eight farms in Central Kentucky (2009-2010). Parasitol Res. 109(4):1193-7. PMID 21499750.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of October 13, 2024


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Antiparasitics


PubChem