130693-82-2 Dorzolamide HCl AKSci J10249
 
 
Loading Please Wait...
  J10249    
Dorzolamide HCl, >98% (HPLC), powder
 
Trusopt
Cosopt
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride
IDENTITY
CAS Number:130693-82-2
MDL Number:MFCD00884659
MF:C10H16N2O4S3.HCl
MW:360.90
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:283-285°C
Optical Rotation:-8° (c=1,MeOH)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: <1mg/mL; H2O: 14mg/mL; EtOH: <1mg/mL
Application(s):Carbonic anhydrase inhibitor
Form:HCl salt

REVIEW
 A carbonic anhydrase inhibitor. The drug is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

REFERENCES
[1]Mincione F, Starnotti M, Masini E, Bacciottini L, Scrivanti C, Casini A, Vullo D, Scozzafava A, Supuran CT (2005). Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorg Med Chem Lett. 15(17):3821-7. PMID 16039853.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335; H302; H373

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 9, 2025


Download SDS Request COA

All products are stocked and shipped from the SF Bay, California, USA via FedEx, UPS or DHL.
All batches backed with full quality assurance.
⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Ophthalmology, Carbonic Anhydrase Inhibitors


PubChem