130693-82-2 Dorzolamide HCl AKSci J10249
 
 
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  J10249    AKSci Reference Standard
Dorzolamide HCl
, >98% (HPLC), powder
 
Trusopt
Cosopt
4H-Thieno[2,3-b]thiopyran-2-sulfonamide, 4-(ethylamino)-5,6-dihydro-6-methyl-, 7,7-dioxide, hydrochloride




IDENTITY
CAS Number:130693-82-2
MDL Number:MFCD00884659
MF:C10H16N2O4S3.HCl
MW:360.90
SPECIFICATIONS & PROPERTIES
Purity:>98% (HPLC), powder
Spectra:NMR, LCMS, FT-IR, HPLC, Polarimetry
Physical Form:White to off-white crystalline powder
Melting Point:283-285°C
Optical Rotation:-8° (c=1,MeOH)
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: <1mg/mL; H2O: 14mg/mL; EtOH: <1mg/mL
Application(s):Carbonic anhydrase inhibitor
Form:HCl salt

REVIEW

 A carbonic anhydrase inhibitor. The drug is used to lower increased intraocular pressure in open-angle glaucoma and ocular hypertension.

REFERENCES
[1]Mincione F, Starnotti M, Masini E, Bacciottini L, Scrivanti C, Casini A, Vullo D, Scozzafava A, Supuran CT (2005). Carbonic anhydrase inhibitors: design of thioureido sulfonamides with potent isozyme II and XII inhibitory properties and intraocular pressure lowering activity in a rabbit model of glaucoma. Bioorg Med Chem Lett. 15(17):3821-7. PMID 16039853.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of July 11, 2020

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Ophthalmology, Carbonic Anhydrase Inhibitors


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