59277-89-3 Acycloguanosine AKSci J10243
 
 
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  J10243    AKSci Reference Standard
Acycloguanosine, 99% (HPLC), powder
 
Aciclovir
Zovirax
9-[(2-Hydroxyethoxy)methyl]guanine
more..
IDENTITY
CAS Number:59277-89-3
MDL Number:MFCD00057880
MF:C8H11N5O3
MW:225.2
EINECS:261-685-1
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:256-262°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 7mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):viral DNA polymerase
Form:Free Base

REVIEW
 A guanosine analogue antiviral drug. Aciclovir differs from previous nucleoside analogues in containing only a partial nucleoside structure: the sugar ring is replaced with an open-chain structure. It is selectively converted into acyclo-guanosine monophosphate (acyclo-GMP) by viral thymidine kinase, which is far more effective (3000 times) in phosphorylation than cellular thymidine kinase.

REFERENCES
[1]Vanpouille C, Lisco A, Introini A, Grivel JC, Munawwar A, Merbah M, Schinazi RF, Derudas M, McGuigan C, Balzarini J, Margolis L. (2012). Exploiting the anti-HIV-1 activity of acyclovir: suppression of primary and drug-resistant HIV isolates and potentiation of the activity by ribavirin. Antimicrob Agents Chemother. 56(5):2604-11. PMID 22314523.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of June 27, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antivirals, NRTIs
 Nucleobases > Nucleosides
 Nucleobases > Nucleosides


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