REVIEW Amlodipine benzenesulfonate is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and thereby reducing blood pressure. In angina, amlodipine increases blood flow to the heart muscle.
Arrowsmith, John E.; Campbell, Simon F.; Cross, Peter E.; Stubbs, John K.; Burges, Roger A.; Gardiner, Donald G.; Blackburn, Kenneth J. Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents Journal of Medicinal Chemistry (1986), 29(9), 1696-702.
Davison, Edward; Wells, James Ingram Amlodipine besylate for treatment of heart disease and hypertension Ger. Offen. (1987), DE 3710457 A1 19871008.
Furlan, Borut; Copar, Anton; Jeriha, Alenka A process for the preparation of amlodipine benzenesulfonate Eur. Pat. Appl. (1994), EP 599220 A1 19940601.
Coppi, Laura; Gasanz, Guillen Yolanda; Campon, Pardo Julio Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization PCT Int. Appl. (2000), WO 2000024714 A1 20000504.
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