111470-99-6 Amlodipine benzenesulfonate AKSci J10238
 
 
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  J10238    AKSci Reference Standard
Amlodipine benzenesulfonate, 99% (HPLC)
 
Amlodipine Besylate
2-[(2-Aminoethoxy)-methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5- pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzene sulfonate
Istin
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IDENTITY
CAS Number:111470-99-6
MDL Number:MFCD00887594
MF:C26H31ClN2O8S
MW:567.05
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Spectra:FT-IR, LCMS, HPLC
Physical Form (at 20°C):White to off-white crystalline powder
Melting Point:195-212°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >=20 mg/mL; H2O: <1mg/mL; EtOH: 14mg/mL
Application(s):Calcium channel blocker
Form:Besylate

REVIEW
 Amlodipine benzenesulfonate is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and thereby reducing blood pressure. In angina, amlodipine increases blood flow to the heart muscle.

REFERENCES
[1]Arrowsmith, John E.; Campbell, Simon F.; Cross, Peter E.; Stubbs, John K.; Burges, Roger A.; Gardiner, Donald G.; Blackburn, Kenneth J. Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents Journal of Medicinal Chemistry (1986), 29(9), 1696-702.
[2] Davison, Edward; Wells, James Ingram Amlodipine besylate for treatment of heart disease and hypertension Ger. Offen. (1987), DE 3710457 A1 19871008.
[3] Furlan, Borut; Copar, Anton; Jeriha, Alenka A process for the preparation of amlodipine benzenesulfonate Eur. Pat. Appl. (1994), EP 599220 A1 19940601.
[4] Coppi, Laura; Gasanz, Guillen Yolanda; Campon, Pardo Julio Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization PCT Int. Appl. (2000), WO 2000024714 A1 20000504.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of January 19, 2022

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


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