88150-42-9 Amlodipine AKSci J10237
 
 
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  J10237    
Amlodipine
, 99% (HPLC)
 
UK-48340




IDENTITY
CAS Number:88150-42-9
MDL Number:MFCD00864687
MF:C20H25ClN2O5
MW:408.88
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White to off-white crystalline powder
Melting Point:134-136°C
Long-Term Storage:Store at room temperature
UN #:UN2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Application(s):Long-acting calcium channel blocker

REVIEW

 Amlodipine benzenesulfonate is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and thereby reducing blood pressure. In angina, amlodipine increases blood flow to the heart muscle.

REFERENCES
[1]Arrowsmith, John E.; Campbell, Simon F.; Cross, Peter E.; Stubbs, John K.; Burges, Roger A.; Gardiner, Donald G.; Blackburn, Kenneth J. Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents Journal of Medicinal Chemistry (1986), 29(9), 1696-702.
[2] Coppi, Laura; Gasanz, Guillen Yolanda; Campon, Pardo Julio Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization PCT Int. Appl. (2000), WO 2000024714 A1 20000504.
[3] Peters, Theodorus H. A.; Benneker, Franciscus B. G.; Slanina, Pavel; Bartl, Jiri Process for making amlodipine and related compounds via cyclocondensation of 2-(o-chlorobenzylidene)-4-(2-phthalimidoethoxy)acetoacetates with 3-aminocrotonates U.S. Pat. Appl. Publ. (2002), US 20020143046 A1 20021003.
[4] Preparation of amlodipine hemimaleate and usage in pharmaceutical formulations to treat angina and high blood pressure Ger. ebrauchsmusterschrift (2002), DE 20116391 U1 20020131.

GHS

Pictograms

Signal Word
Danger

Hazard Statements
H301; H318; H373; H400; H410

Precautionary Statements
P260; P280; P301+P310; P301+P350+P338; P405:P501


Current as of January 18, 2019


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CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers


PubChem
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