88150-42-9 Amlodipine AKSci J10237
 
 
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  J10237    AKSci Reference Standard
Amlodipine, 99% (HPLC), powder
 
UK-48340
IDENTITY
CAS Number:88150-42-9
MDL Number:MFCD00864687
MF:C20H25ClN2O5
MW:408.88
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:134-136°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Application(s):Long-acting calcium channel blocker

REVIEW
 Amlodipine benzenesulfonate is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and thereby reducing blood pressure. In angina, amlodipine increases blood flow to the heart muscle.

REFERENCES
[1]Arrowsmith, John E.; Campbell, Simon F.; Cross, Peter E.; Stubbs, John K.; Burges, Roger A.; Gardiner, Donald G.; Blackburn, Kenneth J. Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents Journal of Medicinal Chemistry (1986), 29(9), 1696-702.
[2] Coppi, Laura; Gasanz, Guillen Yolanda; Campon, Pardo Julio Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization PCT Int. Appl. (2000), WO 2000024714 A1 20000504.
[3] Peters, Theodorus H. A.; Benneker, Franciscus B. G.; Slanina, Pavel; Bartl, Jiri Process for making amlodipine and related compounds via cyclocondensation of 2-(o-chlorobenzylidene)-4-(2-phthalimidoethoxy)acetoacetates with 3-aminocrotonates U.S. Pat. Appl. Publ. (2002), US 20020143046 A1 20021003.
[4] Preparation of amlodipine hemimaleate and usage in pharmaceutical formulations to treat angina and high blood pressure Ger. ebrauchsmusterschrift (2002), DE 20116391 U1 20020131.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H318; H373; H400; H410

Precautionary Statements
P260; P280; P301+P310; P301+P350+P338; P405; P501

Current as of April 16, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Calcium Channel Blockers


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