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Long-acting calcium channel blocker
REVIEW Amlodipine benzenesulfonate is a long-acting dihydropyridine calcium channel blocker used as an antihypertensive and in the treatment of angina pectoris. It acts by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance and thereby reducing blood pressure. In angina, amlodipine increases blood flow to the heart muscle.
Arrowsmith, John E.; Campbell, Simon F.; Cross, Peter E.; Stubbs, John K.; Burges, Roger A.; Gardiner, Donald G.; Blackburn, Kenneth J. Long-acting dihydropyridine calcium antagonists. 1. 2-Alkoxymethyl derivatives incorporating basic substituents Journal of Medicinal Chemistry (1986), 29(9), 1696-702.
Coppi, Laura; Gasanz, Guillen Yolanda; Campon, Pardo Julio Intermediate for the synthesis of amlodipine, preparation process and corresponding utilization PCT Int. Appl. (2000), WO 2000024714 A1 20000504.
Peters, Theodorus H. A.; Benneker, Franciscus B. G.; Slanina, Pavel; Bartl, Jiri Process for making amlodipine and related compounds via cyclocondensation of 2-(o-chlorobenzylidene)-4-(2-phthalimidoethoxy)acetoacetates with 3-aminocrotonates U.S. Pat. Appl. Publ. (2002), US 20020143046 A1 20021003.
Preparation of amlodipine hemimaleate and usage in pharmaceutical formulations to treat angina and high blood pressure Ger. ebrauchsmusterschrift (2002), DE 20116391 U1 20020131.
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