REVIEW 7-Aminocephalosporanic acid (7-ACA) is the core chemical structure and intermediate for the synthesis of cephalosporin antibiotics and their intermediates. It can be obtained by chemoenzymatic hydrolysis of cephalosporin C. The enzymes responsible for the production. of 7-aminocephalosporanic acid (7-ACA) are called cephalosporin acylases (CPC acylases), which hydrolyze cephalosporins to 7-ACA.
REFERENCES
[1]
Abraham EP. Cephalosporins 1945-1986. Drugs. 1987;34 Suppl 2:1-14.
[2]
Matsumoto K. Production of 6-APA, 7-ACA, and 7-ADCA by immobilized penicillin and cephalosporin amidases. Bioprocess Technol. 1993;16:67-88.
[3]
Kumar KK, Sudhakaran V, Deshpande BS, Ambedkar SS, Shewale JG. Cephalosporin acylases: enzyme production, structure and application in the production of 7-ACA.
[4]
Riethorst, Waander; Reichert, Arno An industrial view on enzymes for the cleavage of cephalosporin C Chimia (1999), 53(12), 600-607.
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