50-27-1 Estriol AKSci J10208
 
 
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  J10208    AKSci Reference Standard
Estriol
, >98% (HPLC)
 
1,3,5(10)-Estratriene-3,16α,17β-triol
16α-Hydroxyestradiol
3,16α,17β-Trihydroxy-1,3,5(10)-estratriene




IDENTITY
CAS Number:50-27-1
MDL Number:MFCD00003691
MF:C18H24O3
MW:288.38
EINECS:200-022-2
BRN:2508172
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:281-282°C
Optical Rotation:+56.8° (c=1, in 95% ethanol)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Estriol levels can be measured to give an indication of the general health of the fetus. DHEA-S is produced by the adrenal cortex of the fetus. This is converted to estriol by the placenta. If levels of unconjugated estriol are abnormally low in a pregnant woman, this may indicate a problem with the development of the child. The drug interacts with a target cell receptor. When the estrogen receptor has bound its ligand it can enter the nucleus of the target cell, and regulate gene transcription which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estriol upon the target cell. Estrogens increase the hepatic synthesis of sex hormone binding globulin (SHBG), thyroid-binding globulin (TBG), and other serum proteins and suppress follicle-stimulating hormone (FSH) from the anterior pituitary.

REFERENCES
[1]Soldan SS, Alvarez Retuerto AI, Sicotte NL, Voskuhl RR: Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol. 2003 Dec 1;171(11):6267-74.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H351; H360

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501


Current as of June 18, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES

 APIs and Bioactives > Steroid Hormones


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