55268-74-1 Praziquantel AKSci J10194
 
 
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  J10194    AKSci Reference Standard
Praziquantel
, 99% (HPLC)
 
Anthelminic, Neurogenic
2-(Cyclohexylcarbonyl)-1,2,3,6,7-11b-hexahydro-4H-pyrazino[2,1-aisoquinolin-4-one




IDENTITY
CAS Number:55268-74-1
MDL Number:MFCD00058531
MF:C19H24N2O2
MW:312.41
BRN:761557
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Spectra:NMR, LCMS, FT-IR, HPLC
Physical Form:White powder
Melting Point:139-143°C
Long-Term Storage:Store long-term at -20°C

REVIEW

 Praziquantel works by causing severe spasms and paralysis of the worms' muscles. This paralysis is accompanied - and probably caused - by a rapid Ca 2+ influx inside the schistosome. Morphological alterations are another early effect of praziquantel. These morphological alterations are accompanied by an increased exposure of schistosome antigens at the parasite surface. The worms are then either completely destroyed in the intestine or passed in the stool. An interesting quirk of praziquantel is that it is relatively ineffective against juvenile schistosomes. While initially effective, effectiveness against schistosomes decreases until it reaches a minimum at 3-4 weeks. Effectiveness then increases again until it is once again fully effective at 6-7 weeks. Glutathione S-transferase (GST), an essential detoxification enzyme in parasitic helminths, is a major vaccine target and a drug target against schistosomiasis. Schistosome calcium ion channels are currently the only known target of praziquantel.

REFERENCES
[1]Opposing Roles of Voltage-Gated Ca2+ Channels in Neuronal Control of Regenerative Patterning Dan Zhang, John D. Chan, et al. J. Neurosci. 31, 15983-15995, (2011)
[2] Cytochalasin D abolishes the schistosomicidal activity of praziquantel. Pica-Mattoccia, L., et al. Exp. Parasitol. 115, 344-351, (2007)
[3] Doenhoff MJ, Cioli D, Utzinger J: Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis. Curr Opin Infect Dis. 2008 Dec;21(6):659-67.
[4] McManus DP, Loukas A: Current status of vaccines for schistosomiasis. Clin Microbiol Rev. 2008 Jan;21(1):225-42.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of August 21, 2019

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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For research use only. Not for diagnostic or therapeutic use.
Not for human use.


CATEGORIES

 APIs and Bioactives > Antiparasitics, Veterinary


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