[50-55-5] Reserpine AKSci J10192
 
 
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  J10192    
Reserpine
, 99% (HPLC)
 
11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester




IDENTITY
CAS Number:[50-55-5]
MDL Number:MFCD00005091
MF:C33H40N2O9
MW:608.68
EINECS:200-047-9
BRN:102014
SPECIFICATIONS & PROPERTIES
Purity:99% (HPLC)
Available Spectra:LCMS, HPLC, Polarimetry
Physical Form:White to light yellow-brown powder
Melting Point:260-265°C
Optical Rotation:-126° (c=1, CHCl3)
Long-Term Storage:Store at room temperature

BIOLOGICAL INFO
Solubility:DMSO: 13mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Vesicular monoamine transporter (VMAT) blocker; Adrenergic Uptake Inhibitor
Form:Free Base

REVIEW

 An indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms. Reserpine irreversibly blocks the vesicular monoamine transporter (VMAT). This normally transports free norepinephrine, serotonin, and dopamine from the cytoplasm of the presynaptic nerve terminal into storage vesicles for subsequent release into the synaptic cleft (exocytosis). Unprotected neurotransmitters are metabolized by MAO (as well as by COMT) in the cytoplasm and consequently never reach the synapse.

REFERENCES
[1]Sun H (2012). Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism. Bioorg Med Chem Lett. 22(2):989-95. PMID 22197392
[2] Ashe KM, Chiu WL, Khalifa AM, Nicolas AN, Brown BL, De Martino RR, Alexander CP, Waggener CT, Fischer-Stenger K, Stewart JK (2011). Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain. Neuro Endocrinol Lett. 32(3):253-8. PMID 21712771.

GHS

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501


Current as of November 17, 2017


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CATEGORIES

 APIs and Bioactives > Alkaloids, Antipsychotics, Hypertension


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