50-28-2 Estradiol AKSci J10189
 
 
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  J10189    AKSci Reference Standard
Estradiol, >98% (HPLC)
 
beta-Estradiol
1,3,5-Estratriene-3,17beta-diol
17beta-Estradiol
more..
IDENTITY
CAS Number:50-28-2
MDL Number:MFCD00003693
MF:C18H24O2
MW:272.38
EINECS:200-023-8
BRN:1914275
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:175-181°C
Optical Rotation:+76° - +83° (c=1, Dioxane)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 54mg/mL; H2O: <1mg/mL; EtOH: 23mg/mL
Application(s):Estrogen receptors
Form:Free Base

REVIEW
 A sex hormone. Estradiol enters cells freely and interacts with a cytoplasmic target cell receptor. After the estrogen receptor has bound its ligand, estradiol can enter the nucleus of the target cell, and regulate gene transcription, which leads to formation of messenger RNA. The mRNA interacts with ribosomes to produce specific proteins that express the effect of estradiol upon the target cell.

REFERENCES
[1]Nweze IC, Smith JW, Zhang B, Klinge CM, Lakshmanan J, Harbrecht BG (2012). 17beta-Estradiol attenuates cytokine-induced nitric oxide production in rat hepatocyte. J Trauma Acute Care Surg. 73(2):408-12. PMID 22846947.
[2] Yang W, Zhou H, Cicek N (2012). Removal mechanisms of 17β-estradiol and 17α-ethinylestradiol in membrane bioreactors. Water Sci Technol. 66(6):1263-9. PMID 22828304.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H351; H360; H362

Precautionary Statements
P201; P202; P260; P263; P264; P270; P281; P308+P313; P405; P501

Current as of October 4, 2023

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise. They are not sold to individuals. Additional restrictions may apply.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Estradiol, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Steroid Hormones


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