31430-15-6 Flubendazole AKSci J10180
 
 
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  J10180    
Flubendazole, >99% (HPLC)
 
Methyl [5-(4-fluorobenzoyl)-1H-benzimidazol-2-yl]carbamate
Flumoxanal
[5-(4-Fluorobenzoyl)benzimidazol-2-yl]carbamic acid methyl ester
IDENTITY
CAS Number:31430-15-6
MDL Number:MFCD00871999
MF:C16H12FN3O3
MW:313.28
EINECS:250-624-4
BRN:763480
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:290°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Anthelmintic agent for MDAY-D2 cells

REVIEW
 Flubendazole is a broad-spectrum anthelmintic. It is used by veterinarians for protection against internal parasites and worms in dogs and cats. It is also available for human use to treat worm infections. It is available OTC in Europe. Flubendazole inhibits cytoplasmic microtubules in the intestinal or absorptive cells of the worms, thus inhibiting glucose uptake and glycogen storage depletion, leading to death of the worms within days.

REFERENCES
[1]Van Gelder, Josephus L. H.; Raeymaekers, Alfons H. M.; Roevens, Leopold F. C. Anthelmintic alkyl N-[5(6)-acyl-2-benzimidazolyl] carbamates Ger. Offen. (1971), DE 2029637 A 19710218.
[2] Raeymaekers, A. H. M.; Van Gelder, J. L. H.; Roevens, L. F. C.; Janssen, P. A. J Synthesis and anthelmintic activity of alkyl-(5-acyl-1H-benzimidazol-2-yl)carbamates Arzneimittel-Forschung (1978), 28(4), 586-94.
[3] Raeymaekers AH, Van Gelder JL, Roevens LF, Janssen PA. Synthesis and anthelminthic activity of alkyl-(5-acyl-1-H-benzimidazol-2-yl) carbamates. Arzneimittelforschung. 1978;28(4):586-94.
[4] Rossignol JF, Maisonneuve H Benzimidazoles in the treatment of trichuriasis: a review. Ann Trop Med Parasitol. 1984 Apr;78(2):135-44.
[5] Thienpont D, Vanparijs O, Niemegeers C, Marsboom R. Biological and pharmacological properties of flubendazole. Arzneimittelforschung. 1978;28(4):605-12.
[6] Penot C, Picot H, Lavarde V.Therapeutic trials of a new anti-helminthic in Colombian Amazonia: flubendazole]. Bull Soc Pathol Exot Filiales. 1978 Jul-Oct;71(4-5):370-5.
[7] Michiels M, Hendriks R, Heykants J, van den Bossche H. The pharmacokinetics of mebendazole and flubendazole in animals and man. Arch Int Pharmacodyn Ther. 1982 Apr;256(2):180-91.
[8] Cook GC.Use of benzimidazole chemotherapy in human helminthiases: indications and efficacy Parasitol Today. 1990 Apr;6(4):133-6.
[9] Mackenzie CD, Geary TG. Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs.Expert Rev Anti Infect Ther. 2011 May;9(5):497-501.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 19, 2024


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CATEGORIES
 APIs and Bioactives > Antiparasitics


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